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Full Description
This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume.
Contents
Section I-- Identification and Measurement of Constitutive Activity
Constitutive activity at the cannabinoid CB1 receptor and behavioral responses
Katherine E. Hanlon and Todd W. Vanderah
Detecting constitutive activity and protean agonism at the cannabinoid-2 receptor.
Massimiliano Beltramo, Rossella Brusa, Isabella Mancini, Paola Scandroglio, Massimiliano. Beltramo
Modulation of constitutive activity of the ghrelin receptor by use of pharmacological tools as well as mutagenesis
Birgitte Holst and Jacek Mokrosiński
Assessment of constitutive activity and internalization of GPR54 (Kiss1-r).
Macarena Pampillo and Andy Videsh Babwah
Assessment of Constitutive Activity in EP Prostanoid Receptors
Hiromichi Fujino, Toshihiko Murayama, and John W. Regan
α1D-Adrenergic receptors: constitutive activity and reduced expression at the plasma membrane
J Adolfo Garcia-Sáinz, M. Teresa Romero-Ávila and Luz del Carmen Medina
Constitutive activity of the histamine H1 receptor
Saskia Nijmeijer, Rob Leurs and Henry F Vischer
Constitutive activity of somatostatin receptor subtypes
Anat Ben-Shlomo, Kolja Wawrowsky and Shlomo Melmed
Assessment of homologous internalization of constitutively active N111G mutant of AT1 receptor
Mohiuddin Ahmed Bhuiyan and Takafumi Nagatomo
Methods to detect cell surface expression and constitutive activity of GPR6
Balakrishna M. Prasad, Bettye Hollins and Nevin A. Lambert
β3-adrenoceptor agonists and (antagonists as) inverse agonists: history, perspective, constitutive activity and stereospecific binding.
Maria Grazia Perrone and Antonio Scilimati
Constitutive Activity of the Lutropin Receptor and its Allosteric Modulation by Receptor Heterodimerization
Deborah L. Segaloff
Assessing Constitutive Activity of Extracellular Calcium-Sensing Receptors in Vitro and in Bone
Wenhan Chang, Melita Dvorak, and Dolores Shoback
Constitutive Activity of Neural Melanocortin Receptors.
Ya-Xiong Tao, Hui Huang, Zhi-Qiang Wang, Fan Yang, Jessica N. Williams, and Gregory V. Nikiforovich
Measurement of Constitutive Activity of BMP Type I receptors
Peter ten Dijke
Probing the CA among dopamine D1 and D5 receptors and their mutants
Bianca Plouffe, Jean-Philippe D'Aoust, Vincent Laquerre, Binhui Liang and Mario Tiberi
Identification of Gain-of-Function Variants of the Human Prolactin Receptor
Vincent Goffin, Roman L. Bogorad, and Philippe Touraine
Investigations of Activated ACVR1/ALK2, a Bone Morphogenetic Protein (BMP) Type I Receptor that Causes Fibrodysplasia Ossificans Progressiva
Frederick. Kaplan, Petra Seemann, Julia Haupt, Meiqi Xu, Vitali Lounev, Mary Mullins, Eileen M. Shore
Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations
Joaquin Lado-Abeal, Leah R. Quisenberry, and Isabel Castro-Piedras
Assessment of constitutive activity of a G protein-coupled receptor, Cpr2, in Cryptococcus neoformans by heterologous and homologous methods
Chaoyang Xue, Yina Wang, and Yen-Ping Hsueh
In vitro and in vivo assessment of mu opioid receptor constitutive activity.
Edward J. Bilsky, Denise Giuvelis, Melissa D. Osborn, Christina M. Dersch, Heng Xu and Richard B. Rothman
Constitutively active µ-opioid methods
Mark. Connor and John Traynor
Protein Kinase Ck2 is a Constitutively-Active Enzyme That Promotes Cell Survival: Strategies To Identify Ck2 Substrates and Manipulate Its Activity In Mammalian Cells
Jacob P. Turowec, James S. Duncan, Ashley C. French, Laszlo Gyenis, Nicole A. St. Denis, Greg J. Vilk, and David W. Litchfield
Assessment of Ck2 Constitutive Activity In Cancer Cells
Maria Ruzzene, Giovanni Di Maira, Kendra Tosoni, and Lorenzo A. Pinna
Structural basis of the constitutive activity of protein kinase CK2
Birgitte B. Olsen, Barbara Guerra, Karsten Niefind and Olar-Georg Issinger font error
Measuring the Constitutive Activation of c-Jun N-terminal Kinase Isoforms
Ryan T. Nitta, Shawn S. Badal, and Albert J. Wong
Measurement of constitutive MAPK and PI3K/AKT signaling activity in human cancer cell lines.
Keiran S.M. Smalley
Constitutive activity of GPR40/FFA1: Intrinsic or assay dependent?
Leigh A Stoddart and Graeme Milligan
Constitutive activity of TRP channels: methods for measuring the activity and its outcome
Baruch Minke
Measurement of Orexin (Hypocretin) and Substance P Effects On Constitutively Active Inward Rectifier K+ Channels in Brain Neurons
Yasuko Nakajima and Shigehiro Nakajima
Characterization of G protein receptor kinase 4 and measuring its constitutive activity in vivo
Bradley T. Andresen
Voltage-clamp based methods for the detection of constitutively active acetylcholine-gated IK,ACh channels in the diseased heart
Niels Voigt, Samy Makary, Stanley Nattel, Dobromir Dobrev
Assaying Wave and WASH complex constitutive activities towards the Arp2/3 complex.
Emmanuel DERIVERY and Alexis GAUTREAU
