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Full Description
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
Contents
Proteomics technologies for the global identification and quantification of proteins
Ian A. Brewis and P. Brennan
Targeted metabolomics and mass spectrometry
E. Dudley, M. Yousef, Y. Wang, W.J. Griffiths
Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling
Tatyana Karabencheva and Christo Christov
Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling
Jonathan G. L. Mullins, Seo-Kyung Chung and Mark I. Rees
Positive and Negative Modulation of Nicotinic Receptors
Hugo R. Arias
Sonochemically Born Proteinaceous Micro- and Nanocapsules
Elena D. Vassileva and Neli S. Koseva
