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基本説明
Includes coverage of new topics in epigenetics, such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders.
Full Description
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon.This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.
Contents
1. EpigeneticsSECTION I: Molecular Mechanisms of Epigenetics2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals 3. Mechanisms of Histone ModificationsSECTION II: Additional Epigenetic Processes4. The Epigenetics of Non-coding RNA5. Prions and Prion-like Phenomena in Epigenetic Inheritance6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies7. Polycomb Mechanisms and Epigenetic Control of Gene ActivitySECTION III: Epigenetic Technology8. Analysis of Gene-specific DNA Methylation9. Methods for Assessing Genome-wide DNA Methylation10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus12. Assessing Epigenetic InformationSECTION IV: Model Organisms of Epigenetics13. Epigenetics of Eukaryotic Microbes14. Drosophila Epigenetics15. Mouse Models of Epigenetic Inheritance16. Epigenetic Regulatory Mechanisms in PlantsSECTION V: Metabolism and Epigenetics 17. Metabolic Regulation of DNA Methylation in Mammals18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling SECTION VI: Functions of Epigenetics19. Epigenetics, Stem Cells and Cellular Differentiation 20. Epigenetic Basis of Skeletal Muscle Regeneration21. Epigenetics of X Chromosome Inactivation22. Genomic Imprinting23. Epigenetics of Memory Processes24. Transgenerational Epigenetics25. Aging EpigeneticsSECTION VII: Evolutionary Epigenetics 26. Epigenetics in Adaptive Evolution and DevelopmentSECTION VIII: Epigenetic Epidemiology27. The Effects of Diet on Epigenetic Processes28. Environmental Agents and Epigenetics29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis 30. DNA Methylation Profiles in the 5'-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome31. Population PharmacoepigenomicsSECTION IX: Epigenetics and Human Disease32. Cancer Epigenetics33. The Role of Epigenetics in Immune Disorders34. Epigenetics of Brain Disorders35. Complex Metabolic Syndromes and Epigenetics36. Imprinting Disorders in HumansSECTION X: Epigenetic Therapy37. Clinical Applications of Histone Deacetylase Inhibitors
