Progress in Molecular Biology and Translational Science : G Protein-coupled Receptors in Health and Disease (Progress in Molecular Biology and Transla 〈88〉 （1ST）

Tao, Ya-xiong (EDT)

Academic Pr（2009/08発売）

• 製本 Hardcover:ハードカバー版／ページ数 212 p.
• 言語 ENG
• 商品コード 9780123747570
• DDC分類 572

Full Description

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

Contents

1. Rhodopsin-Mediated Retinitis PigmentosaKatherine M. Malanson and Janis Lem2. Human Diseases Associated with GPR54 MutationsMilena Gurgel Teles, Leticia Ferreira Gontijo Silveira, Suzy Bianco and Ana Claudia Latronico3. Diseases Associated with Growth Hormone-releasing hormone Receptor (GHRHR) MutationsMarco Martari and Roberto Salvatori4. The Melanocortin-1 Receptor Gene Polymorphism and Association with Human Skin CancerKimberley A. Beaumont, Yan Yan Liu and Richard A. Sturm5. The Molecular Basis of Adrenocorticotrophin Resistance Syndrome Lucila L K Elias and Adrian J L Clark6. Mutations in melanocortin-4 receptor and human obesityYa-Xiong Tao