Full Description
For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of oxygen biology and hypoxia.
Contents
Section I. Hypoxia-inducible factor
Chapter 1
HIF PAS domains: structure and function
Thomas H. Scheuermann, Jinsong Yang, Lei Zhang, Kevin H. Gardner, and Richard K. Bruick
Chapter 2
Structure-function analysis of HIF
Lorenz Poellinger
Chaper 3
HIF Prolyl Hydroxylase: Purification and Assays of PHD2
Kirsty S. Hewitson, Christopher J. Schofield, Peter J. Ratcliffe
Chapter 4
Determination and modulation of prolyl-4-hydroxylase domain (PHD) oxygen sensor activity
Renato Wirthner, Kuppusamy Balamurugan, Daniel P. Stiehl, Sandra Barth, Patrick Spielmann, Felix Oehme, Ingo Flamme, Dörthe M. Katschinski, Roland H. Wenger and Gieri Camenisch
Chapter 5
Characterisation of ankyrin-repeat containing proteins as substrates of the asparaginyl hydroxylase Factor Inhibiting HIF (FIH-1).
Sarah Linke, Rachel J. Hampton-Smith, Daniel J. Peet
Chapter 6
Transgenic Models to Understand HIF Function
Andrew Doedens and Randall S. Johnson
Chapter 7
The Silencing Approach of the Hypoxia Signalling Pathway"
Edurne Berra and Jacques Pouyssegur
Chapter 8
Cellular and developmental adaptations to hypoxia; a Drosophila perspective
Nuria Magdalena Romero, Andrés Dekanty, Pablo Wappner
Section II. Erythropoietin
Chapter 9
Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligation
Giovanni G. Camici, Thomas Stallmach, Matthias Hermann, Rutger Hassink, Peter Doevendans, Beat Grenacher, Alain Hirschy, Johannes Vogel, Thomas F. Lüscher, Frank Ruschitzka and Max Gassmann
Chapter 10
Control of erythropoietin gene expression and its use in medicine
Wolfgang Jelkmann
Chapter 11
Role of HIF-2 in endothelial development and hematopoiesis
Osamu Ohneda1,3, Masumi Nagano1,3 and Yoshiaki Fujii-Kuriyama
Section III. Hypoxia and adaptation
Chapter 12
ORGAN PROTECTION BY HYPOXIA AND HIF
Wanja M. Bernhardt, Christina Warnecke, Carsten Willam, Michael S. Wiesener and
Kai-Uwe Eckardt
Chapter 13
Hypoxia and regulation of mRNA translation
Marianne Koritzinsky and Bradly G. Wouters
Chapter 14
Hypoxia and the Unfolded Protein Response
Constantinos Koumenis, Meixia Bi, Jiangbin Ye, Douglas Feldman and Albert C. Koong
Section IV. Hypoxia and tumor biology
Chapter 15
Tumor hypoxia in cancer therapy
J. Martin Brown
Chapter 16
HIF Gene Expression in Cancer Therapy
By Denise A. Chan, Adam J. Krieg, Sandra Turcotte, and Amato J. Giaccia
Chapter 17
Analysis of HIF-1 Expression and Its Effects on Invasion and Metastasis
Balaji Krishnamachary, Gregg L. Semenza
Chapter 18
Macrophage migration inhibitory factor (MIF) manipulation and evaluation in tumoral hypoxic adaptation
Millicent Winner, Lin Leng, Wayne Zundel and Robert A. Mitchell
Chapter 19
The von Hippel-Lindau Tumor Suppressor Protein: An Update
William G. Kaelin, Jr.
Chapter 20
Hypoxia Inducible Factor 1 (HIF-1) inhibitors
Giovanni Melillo
Section V. Hypoxia and inflammatory mediators
Chapter 21
Regulation of HIF during Inflammation
Stilla Frede, Utta Berchner-Pfannschmidt, Joachim Fandrey
Chapter 22
Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors
Agnes Görlach, Thomas Kietzmann
Chapter 23
Genetics of mitochondrial electron transport chain in regulating oxygen sensing
Eric L. Bell and Navdeep S. Chandel
Chapter 24
Hypoxia inducible factor-1 (HIF-1) under the control of nitric oxide (NO)
Bernhard Brüne and Jie Zhou
Chapter 25
Hypoxic regulation of NF-κB signalling
Eoin P. Cummins, Katrina M. Comerford, Carsten Scholz, Ulrike Bruning & Cormac T. Taylor
