Full Description
Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad: HIV-1: Molecular Biology and Pathogenesis, Second Edition. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus.
Contents
HIV Therapeutics: Past, Present, and Future
HIV Drug Resistance and Viral Fitness
Inhibitors of HIV-1 Reverse Transcriptase
HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance
HIV-I Integrase Inhibitors: Past, Present, and Future
Selection of HIV Replication Inhibitors: Chemistry and Biology
Maturation or assembly inhibitor compounds against HIV-1
HIV-I Gene Therapy: Promise for the Future
Assessment of HIV Vaccine Development: Past, Present, and Future
CTL immunity approaches for HIV-1 vaccines
humoral immunity approaches for HIV-1 vaccines.
HIV-I-Associated Central Nervous System Dysfunction
Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission
Molecular Epidemiology of HIV-I: An Example of Asia
Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention
Animal Models for AIDS Pathogenesis
SCID-hu mouse models for studying HIV-AIDS and for drug testing.
