キノンおよびキノン酵素B<br>Quinones and Quinone Enzymes (Methods in Enzymology) 〈382〉

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キノンおよびキノン酵素B
Quinones and Quinone Enzymes (Methods in Enzymology) 〈382〉

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  • 製本 Hardcover:ハードカバー版/ページ数 544 p.
  • 言語 ENG
  • 商品コード 9780121827861
  • DDC分類 572

基本説明

Features: Mitochondrial Ubiquinone and Reductases; Anticancer Quinones and Quinone Oxido-Reductases; Quininone Reductases: Chemoprevention, Nutritin; and more.

Full Description


Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.

Contents

Section I1: Mitochondrial Quinone Reductases: Complex I2: Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes3: Targeting Coenzyme Q Derivatives to Mitochondria4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency6: Coenzyme Q Cytoprotective Mechanisms7: Dietary Coenzyme Q10 and Mitochondrial StatusSection II: Anticancer Quinones and Quinone Oxidoreductases8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)10: Diaziridinylbenzoquinones11: Quinone Reductase-Mediated Nitro-Reduction: Clinical Applications12: Bioactivation and Resistance to Mitomycin C13: NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells14: The "Prochaska" Microtiter Plate Bioassay for Inducers of NQO115: Structure-Activity Relationships in Two-Electron Reduction of Quinones16: p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 117: The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases18: Induction of NQO1 in Cancer CellsSection III: Quinone Reductases: Chemoprevention and Nutrition19: Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates20: Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase21: Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens22: Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes23: Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)24: Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview25: Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary BroccoliSection IV: Quinones and Age-Related Diseases26: Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases27: Neuroprotective Actions of Coenzyme Q10 in Parkinson's DiseaseAuthor IndexSubject Index