基本説明
A comprehensive treatise that spans the complete range from basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders.
Full Description
This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases.
Contents
PART I Components of the Organic Extracellular Matrix of Bone and Cartilage
1. Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone
2. Fibrillogenesis and Maturation of Collagens
3. Vitamin K Dependent Proteins of Bone and Cartilage
4. Non-collagenous Proteins; Glycoproteins and Related Proteins
5. Proteoglycans and Glycosaminoglycans
6. Growth Factors
7. Prostaglandins and Proinflammatory Cytokines
8. Integrins and Other Adhesion Molecules
9. Alkaline Phosphatases
10. Acid Phosphatases
11. Matrix Proteinases
PART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage
12. Mineralization, Structure and Function of Bone
13. Bone Structure and Strength
14. The Cells of Bone
15. Signalling in bone
16. Parathyroid Hormone: Structure, Function and Dynamic Actions
17. Interaction of Parathyroid Hormone-Related Peptide with the Skeleton
18. The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology
19. Sex Steroid Effects on Bone Metabolism
20. Physiology of Calcium and Phosphate Homeostasis
21. The Central Control of Bone Remodelling
22. New Concepts in Bone Remodeling
23. Products of Bone Collagen Metabolism
24. Supramolecular Structure of Cartilage Matrix
25. Products of Cartilage Metabolism
26. Fluid Dynamics of the Joint Space and Trafficking of Matrix Products
27. Transgenic Models of Bone Disease
PART III Markers of Bone and Cartilage Metabolism
28. The Role of Genetic Variation in Osteoporosis
29. Measurement of Calcium, Phosphate and Magnesium
30. Measurement of Parathyroid Hormone
31. New Horizons for Assessment of Vitamin D Status in Man
32. Measurement of Biochemical Markers of Bone Formation
33. Measurement of Biochemical Markers of Bone Resorption
34. Variability in the measurement of biochemical markers of bone turnover
35. Validation of Biochemical Markers of Bone Turnover
36. Genetic Markers of Joint Disease
37. Body Fluid Markers of Cartilage Metabolism
38. Laboratory Assessment of Postmenopausal Osteoporosis
39. Monitoring of Anabolic Treatment
40. Monitoring of anti-resorptive treatment
41. Age-Related Osteoporosis and Skeletal Markers of Bone Turnover
42. Osteoporosis in Men
43. Steroid-Induced Osteoporosis
44. Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment
45. Secondary Osteoporosis
46. Osteomalacia and Rickets
47. Assessment of Bone and Joint Diseases: Renal Osteodystrophy
48. Primary Hyperparathyroidism
49. Paget's Disease of Bone
50. Metastatic Bone Disease
51. Rare Bone Diseases
52. Osteogenesis Imperfecta
53. Rheumatoid Arthritis and Other Inflammatory Joint Pathologies
54. Osteoarthritis and Degenerative Spine Pathologies
