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Description
• Extensively revised and updated all chapters, in line with recommendations of CBME and subject requirement.
• Important points have been threaded throughout the text in yellow boxes, reemphasizing the core concepts.
• Selected advanced learning concepts are highlighted in blue boxes or enclosed in numbered boxes for postgraduate students and inquisitive undergraduates.
• Nearly all figures have been modified or redrawn to make reading soothing for better retention.
• Inclusion of new questions at the end of book for self-assessment of the topics studied.
• Clinical cases along with case discussions – important pillar of the CBME are presented for problem-based learning and knowledge.
• Addition of new chapter on Processing and Targeting of Proteins.
• Systematically modified chapters on Cancer; Recombinant DNA Technology and Genetic Engineering; Molecular Biology: Eukaryotic Gene Expression; Immunology; Organ Function Tests; Carbohydrates and Lipid Metabolism; and Energy Metabolism and Nutrition to cater to various competencies recommended by new curriculum.
• Inclusion of clinical boxes in each chapter highlighting horizontal- and vertical integration of topics to foster solid understanding.
• Enriched text with additional new line diagrams, clinical photographs, tables and boxes for easy understanding and reproducibility.
• Multiple-choice questions have been given chapterwise to evaluate the level of understanding and memory recall of the students.
Online resources at www.medenact.com
• Complementary access to full e-book
• Whiteboard Lectures
• Question Bank
Table of Contents
Competency Map: Biochemistry
SECTION 1 Biomolecules
1 Water, Buffers and Acid–Base Chemistry
2 Chemistry of Carbohydrates
3 Chemistry of Lipids
4 Amino Acids, Peptides and Proteins
5 Plasma Proteins and Immunoglobulin
6 Enzymes
7 Enzymes in Clinical Diagnosis
8 Characteristics of Cells and Membrane Transport
9 Extracellular Matrix
SECTION 2 Metabolism
10 Overview of Metabolism and Cell Bioenergetics
11 Metabolism of Carbohydrates I: Mainline Metabolic Pathways
12 Metabolism of Carbohydrates II: Glycogen Metabolism and Regulation
13 Metabolism of Carbohydrates III: Secondary Pathways and Regulation of Blood Glucose Levels
14 Metabolism of Lipids I: Metabolism of Fatty Acids and Compound Lipids
15 Metabolism of Lipids II: Lipoproteins, Cholesterol and Prostaglandins
16 Amino Acid and Protein Metabolism I: Nitrogen Metabolism and Urea Cycle
17 Amino Acid and Protein Metabolism II: Catabolism of Carbon Skeletons and Inherited Disorders
18 Amino Acid and Protein Metabolism III: Biosynthesis and Derivatives
19 Biological Oxidation and Electron Transport Chain
20 Integration of Metabolism
SECTION 3 Physiological Chemistry
21 Haem Metabolism
22 Oxygen Transporters: Haemoglobin and Myoglobin
SECTION 4 Nutrition
23 Gastrointestinal Pathobiochemistry
24 Energy Metabolism and Nutrition
25 Vitamins
26 Minerals
SECTION 5 Nucleic Acid Metabolism and Molecular Biology
27 Nucleic Acid Chemistry and Nucleotide Metabolism
28 Molecular Biology I: DNA Structure, Genetic Role and Replication
29 Molecular Biology II: Mutagenesis and DNA Repair
30 Molecular Biology III: Transcription and Translation
31 Molecular Biology IV: Regulation of Prokaryotic Gene Expression and Molecular Genetics
32 Molecular Biology V: Eukaryotic Chromosome and Gene Expression
33 Recombinant DNA Technology and Genetic Engineering
SECTION 6 Clinical Biochemistry
34 Acid–Base Chemistry and Associated Disorders
35 Sodium, Potassium and Water Homoeostasis
36 Calcium and Phosphate: Metabolism and Regulation
37 Organ Function Tests
38 Cancer
39 Biochemical Techniques
SECTION 7 Biochemical Endocrinology
40 Biochemical Endocrinology
41 Action of Hormone
SECTION 8 Contemporary Topics
42 Free Radicals in Health and Diseases
43 Xenobiotics
44 Immunology
45 Processing and Targeting of Proteins
46 Applications of Radiation and Radioisotopes in Medicine
47 Environmental Pollutants and Toxins
Clinical Case Discussions
Reference Range
Glossary
Index
WHITEBOARD LECTURES
Chapters 1 and 34
1. Acid–Base Balance
Chapter 2
2. Sugar Derivatives
Chapter 3
3. Significance of Cholesterol
Chapters 3, 4 and 11
4. Amphibolic, Amphoteric, Amphipathic
Chapter 4
5. Standard Amino Acids
6. Peptides of Biological Significance
Chapter 5 and 44
7. Primary and Secondary Immune Responses
Chapter 6
8. Enzyme Classification
Chapters 6 and 11
9. Suicide Inhibition
Chapter 8
10. Membrane Lipids and Proteins
11. Membrane Transport
Chapter 9
12. Collagen
Chapter 11
13. Anaplerotic Reactions
Chapters 11, 14 and 20
14. Metabolic Aberrations in Diabetes
Chapter 15
15. Reverse Cholesterol Transport
Chapter 16, 19 and 22
16. Biochemical Basis of Toxicity of Some Agents
Chapter 19
17. Uncouplers
Chapter 20
18. Diagnosis of Diabetes
19. Biochemical Basis of Diabetic Complications
Chapters 21 and 37
20. Chronic Renal Failure
21. Bilirubin Metabolism
22. Porphyrias
Chapter 25
23. Beriberi
24. Pernicious Anaemia
Chapters 25 and 26
25. Anaemia in Deficiency of Various Vitamins and Minerals
Chapter 27
26. Gout
Chapters 27, 40 and 41
27. Pseudogout, Pseudohypoparathyroidism, Pseudo-Cushing Syndrome, etc.
Chapter 29
28. Mutations
Chapter 32
29. RNA Interference
Chapter 34
30. Metabolic Acidosis
31. Metabolic Alkalosis
Chapter 40
32. Cholera and Pertussis
Chapter 44
33. Severe Combined Immunodeficiency Disease
(SCID)
34. T-helper Cells
