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Description
The fourth edition of this leading book provides an authoritative, comprehensive and complete account of the neuronal disorders of the lower gastrointestinal tract in children. The book has been thoroughly revised and updated to reflect major advances that have occurred both in the understanding as well as the treatment of Hirschsprung’s disease.
Contents discuss the latest therapies such as stem cell therapies, the epidemiology and association with multiple endocrine neoplasia and approaches to diagnosis such as radiology and manometry as well as Hirschsprung’s disease in adolescents and adults.
Surgical approaches are thoroughly covered and include a new chapter on intestinal transplantation options. The follow-up care and long-term outcomes of patients who have undergone therapy are also addressed in this edition.
With several new chapters added and the contents updated and re-worked, this edition is authored by the leading current experts in their respective fields. It is a must-have book for pediatric surgeons, pediatricians, gastroenterologists, and colorectal surgeons.
Table of Contents
Hirschsprung’s Disease: A Historical Perspective.- Development of the Enteric Nervous system.- Functional Anatomy of the Enteric System.- Normal Colonic Morphology and Motor Function.- Animal Models of Hirschsprung’s Disease.- Familial Hirschsprung’s Disease.- Genetics of Hirschsprung’s Disease.- Stem cell Therapy for Enteric neuropathies.- Pathophysiology of Hirschsprung’s Disease.- Epidemiology and Clinical Characteristics of Hirschsprung’s Disease.- Associated Anomalies and Syndromes in Hirschsprung’s Disease.- Association between Hirschsprung’s Disease and Multiple Endocrine Neoplasia Type 2a.- Hirschsprung’s Associated Enterocolitis.- Radiological Diagnosis of Hirschsprung’s Disease.- Manometeric Diagnosis of Hirschsprung’s Disease.- Rectal Biopsy for the diagnosis of Hirschsprung’s Disease.- Histopathological Diagnosis of Hirschsprung’s Disease.- Total Colonic Aganglionosis.- Hirschsprung’s Disease in adolescents and adults.- Variants of Hirschsprung’s Disease.- Megacystis-Microcolon-Intestinal Hypoperistalsis syndrome.- Degenerative Hollow Visceral Myopathy Mimicking Hirschsprung’s Disease.- Transanal Pull-Through operation for rectosigmoid Hirschsprung’s Disease.- Laparoscopically Assisted Pull-Through operation for Hirschsprung’s Disease.- Redo Surgery for Hirschsprung’s Disease.- Early and late Complications following Pull-Through operation for Hirschsprung’s Disease.-Morphological Basis of Persistent bowel problems following a properly performed pull-through operation for Hirschsprung’s Disease.- Bowel Management for the treatment of Chronic constipation and soiling in patients operated for Hirschsprung’s Disease.- Inflammatory Bowel Disease in patients with Hirschsprung’s Disease.- Intestinal Transplantation for Total Intestinal Aganglionosis.- Urological and Sexual outcome in patients with Hirschsprung’s Disease.- Longterm Outcome and Quality of life after treatment of Hirschsprung’s Disease.
