Full Description
Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography - mass spectrometry, capillary electrophoresis - mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
Contents
1. NMR-Based Metabolomics in Cancer Research.- 2. Capillary Electrophoresis-Mass Spectrometry for Cancer Metabolomics.- 3. Chemical Isotope Labeling LC-MS for Metabolomics.- 4. Single cell metabolomics by mass spectrometry imaging.- 5. Fatty Acid Metabolism and Cancer.- 6. Metabolomics of Gastric Cancer.- 7. HIF-1α metabolic pathways in human cancer.- 8. Regulation of glycolysis in head and neck cancer.- 9. Metabolomics of oral/head and neck cancer.- 10. Ion chromatography with mass spectrometry for metabolomic analysis.- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids.- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy.- 13. Metabolomics of glioma.- 14. Microbial metabolomics: From methods to translational applications.- 15. Advances in the study of N6-methyladenine in eukaryotes.- 16. NMRBased Metabolomics.- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate.- 18. Tracer-based Cancer Metabolomic Analysis.- 19. Mass spectrometry-based shotgun lipidomics for cancer research.- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
