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Full Description
During recent years, stereochemistry has undergone a phenomenal growth both in theory and practice, with a concomitant increase of interest among the organic chemists, biological chemists, medicinal chemists, and pharmacologists. The present text provides an up-to-date, coherent, and comprehensive account of the subject starting from the fundamentals and leading up to the latest developments as far as practicable. Emphasis has been placed on a symmetry-based approach to molecular chirality, stereochemical terminologies (modern stereochemistry is replete with them), topicity and prostereoisomerism, conformational analysis, dynamic stereochemistry, chiroptical properties, and assignment of absolute configuration to chiral molecules. Dynamic stereochemistry has been discussed with reference to conformation-reactivity correlation, stereoselective synthesis, and pericyclic reactions. A large crosssection of organic reactions with stereochemical implication has been incorporated. Attempts have been made to familiarise the readers with modern instrumental techniques, nuclear magnetic resonance in particular, used for stereochemical investigation. Each chapter is provided with a summary which highlights the main points of the text.
Contents
Molecular Geometry and Chemical Bonding Molecular Symmetry and Chirality Stereoisomerism: Definitions and Classifications Stereoisomerism and Centre of Chirality Stereoisomerism: Axial Chirality, Planar Chirality and Helicity Topicity and Prostereoisomerism Racemisation and Methods of Resolution Determination of Configuration Conformations of Acyclic Molecules Conformations of Cyclic Systems: Monocyclic Compounds Conformations of Cyclic Systems: Fused Ring and Bridged Ring Compounds Dynamic Stereochemistry I: Conformation and Reactivity Dynamic Stereochemistry II: Stereoselective Reactions Dynamic Stereochemistry III: Pericyclic Reactions Molecular Dissymmetry and Chiroptical Properties Molecular Recognition: Chemical and Stereochemical Aspects
