Full Description
A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.
Contents
I. Introduction.- 1 Introduction: Present and Potential Impact of Expression Profiling Studies of Human Tumors.- II. Technical Aspects.- 2 cDNA Microarrays.- 3 Oligonucleotide Microarrays.- 4 Serial Analysis of Gene Expression (SAGE) in Cancer Research.- 5 Tissue Arrays.- 6 Microarray Data Analysis: Cancer Genomics and Molecular Pattern Recognition.- 7 The Role of Tumor Banking and Related Informatics.- III. Applications.- 8 Characterization of Gene Expression Patterns for Classification of Breast Carcinomas.- 9 Microarray Analysis of Colorectal Cancer.- 10 Gene Expression Analysis of Prostate Carcinoma.- 11 Classification of Human Lung Carcinomas by mRNA Expression Profiling.- 12 Molecular Profiling of Bladder Cancer Using High-Throughput DNA Microarrays.- 13 Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications.- 14 Expression Profiling of Pancreatic Ductal Adenocarcinoma.- 15 Gene Expression in Ovarian Carcinoma.- 16 Classification of Pediatric Tumors Using DNA Microarrays.- 17 Transcriptomes of Soft Tissue Tumors: Pathologic and Clinical Implications.- 18 Gene Expression Profiling in Lymphoid Malignancies.- 19 Gene Expression Profiling of Brain Tumors.- 20 Expression Profiling of Bone Tumors.
