Microelectrofluidic Systems : Modeling and Simulation (Nano- and Microscience, Engineering, Technology and Medicine)

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Microelectrofluidic Systems : Modeling and Simulation (Nano- and Microscience, Engineering, Technology and Medicine)

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  • 製本 Hardcover:ハードカバー版/ページ数 257 p.
  • 言語 ENG,ENG
  • 商品コード 9780849312762
  • DDC分類 610.28

Full Description


Composite systems that integrate microelectromechanical and microelectrofluidic (MEF) components with electronics are emerging as the next generation of system-on-a-chip (SOC) designs. However, there remains a pressing need for a structured methodology for MEFS design automation, including modeling techniques and simulation and optimization tools.Integrating top-down and bottom-up design philosophies, Microelectrofluidic Systems presents the first comprehensive design strategy for MEFS. This strategy supports hierarchical modeling and simulation from the component level to the system level. It leads to multi-objective optimization tools valuable in all phases of the design process, from conceptualization to final manufacturing. The authors begin by defining the basic variables and elements needed to describe MEFS behavior, then model that behavior across three layers of abstraction: the low-level component, high-level reconfigurable architecture, and bio/chemical application layers. They have developed a hierarchical integrated design environment with SystemC and present its architecture and associated functional packages.Microelectrofluidic Systems is visionary in its leverage of electronic design principles for microsystem design and heralds a new era of automated SOC design. The strategy it presents holds the potential for significant reductions in design time and life-cycle maintenance costs, and its techniques and tools for robust design and application flexibility can lead to the high-volume production needed for the inevitably growing product market.

Table of Contents

Preface                                            xiii
List of Figures xv
List of Tables xxiii
Introduction 1 (14)
Modeling and Simulation Issues 2 (4)
Modeling and Simulation Needs 6 (3)
Computational Architectures for MEFS 7 (1)
Hierarchical Modeling and Simulation 7 (1)
Advanced Hierarchical Design Methodology 8 (1)
Hierarchical Design and Simulation 8 (1)
Optimization
System Design Language Uniformity 8 (1)
Overview 9 (6)
Hierarchical Modeling 15 (24)
MEFS Dynamic Modeling and Simulation at 16 (15)
Circuit Level
Classification of Dynamic System Models 18 (2)
Fundamental Variables 20 (3)
Relationships between Fundamental 23 (4)
Variables
Kirchhoffian Networks 27 (3)
The Equivalent Circuit Modeling Method 30 (1)
MEFS System-level Modeling and Simulation 31 (5)
MEFS System-level Modeling 32 (3)
MEFS System-level Simulation 35 (1)
Statistical Analysis Capacity 36 (1)
Conclusion 36 (3)
SystemC-based Hierarchical Design Environment 39 (36)
Suitability of Modeling Languages for 41 (25)
Hierarchical Design
VHDL-AMS Suitability for Circuit-level 41 (6)
Modeling and Simulation
VHDL Suitability for System-level 47 (10)
Modeling and Simulation
Performance Language-SLAM 57 (4)
C/C++ and Matlab 61 (2)
SystemC 63 (3)
Building Design Environment with SystemC 66 (7)
Hierarchical Design Environment 66 (1)
System-level Modeling Package 66 (4)
Circuit-level Component Modeling Package 70 (1)
Numerical Simulation Package 71 (1)
Optimization/Verification Package 72 (1)
Conclusion 73 (2)
System-level Simulation and Performance 75 (34)
Evaluation
MEFS Computing and Architecture 76 (10)
Architectural Concepts 77 (1)
Architecture Proposal 78 (1)
Reconfigurable Architectural Functional 79 (1)
Requirements
Potential Architecture 80 (2)
Performance Modeling and Simulation 82 (4)
Hierarchical Modeling and Simulation 86 (3)
Methodology
MEFS Hierarchical Perspective 86 (1)
Hierarchical Performance Evaluation 87 (1)
Strategy
Modeling and Simulation Language 88 (1)
Micro-Chemical Handling System - 89 (11)
Stochastic Performance Modeling 90 (5)
Thermal Catalyzing Process Functionality 95 (2)
Microvalve Lumped-element Nodal Modeling 97 (3)
System Performance Analysis and Design 100 (6)
Optimization
Architectural Optimization 100 (3)
Microsystem Performance Sensitivity 103 (2)
Analysis
Microsystem Performance Estimation with 105 (1)
Traffic Variation
Conclusion 106 (3)
Circuit-level Optimization 109 (74)
Simulation Design Methodology 110 (17)
Bootstrap Method 111 (14)
Factorial Design 125 (2)
Optimization Verification 127 (3)
Subjective Verification 127 (1)
Objective Verification 128 (2)
On-target Design Optimization 130 (12)
Statistical Modeling and Response Analyses 132 (3)
Statistical Modeling of a Microvalve 135 (3)
Search for On-target Design Point 138 (2)
Sensitivity Analysis 140 (2)
Robust Design Optimization 142 (24)
Statistical Response Analysis 143 (6)
Statistical Response Analysis of 149 (9)
Microresonators
Design Optimization of Microvalves 158 (8)
Application Flexibility Optimization 166 (15)
Design Approach 168 (3)
Determining the Performance Flexibility 171 (2)
Optimization Procedure 173 (1)
Case Study: Microvalve Modeling and 174 (7)
Optimal Design
Conclusion 181 (2)
Performance Evaluation 183 (50)
Introduction 184 (4)
Polymerase Chain Reaction (PCR) 184 (1)
PCR Detection for DNA Concentration 185 (2)
PCR Purification 187 (1)
Acquisition Assumption 188 (1)
Continuous-flow PCR System 188 (18)
Three-way Microvalve 189 (1)
Sequential Continuous-flow PCR System 189 (5)
Detectable PCR System 194 (7)
Reconfigurable PCR System 201 (5)
Droplet-based PCR System 206 (6)
A Droplet-based PCR System 206 (1)
Physical Implementation 207 (5)
Comparison between Continuous-flow PCR and 212 (4)
Droplet PCR
System Design Complexity 212 (1)
Performance Evaluation 212 (4)
Scheduling of Microfluidic Operations for 216 (17)
Reconfigurable Two-Dimensional
Electrowetting Arrays
Introduction 219 (1)
Two-dimensional Electrowetting Array 220 (3)
Schedule Optimization 223 (2)
Droplet-based PCR Systems 225 (8)
Conclusion 233 (4)
A VHDL Queuing Model 237 (2)
B Hierarchical Environment with SystemC 239 (4)
References 243 (12)
Index 255