同位体標識化合物の合成と応用(シンポジウム集)<br>Synthesis and Applications of Isotopically Labelled Compounds : Proceedings of the Eighth International Symposium, Boston, USA, 1-5 June 2003 〈8〉

  • ポイントキャンペーン

同位体標識化合物の合成と応用(シンポジウム集)
Synthesis and Applications of Isotopically Labelled Compounds : Proceedings of the Eighth International Symposium, Boston, USA, 1-5 June 2003 〈8〉

  • ただいまウェブストアではご注文を受け付けておりません。 ⇒古書を探す
  • 製本 Hardcover:ハードカバー版/ページ数 494 p.
  • 言語 ENG,ENG
  • 商品コード 9780470863657
  • DDC分類 547.1388

Table of Contents

Organizing Committee                               xix
Sponsoring Organizations xx
Exhibitors xxi
Preface xxiii
IIS Award xxv
Melvin Calvin Award xxvi
Plenary lectures xxviii
Sponsored lectures xxviii
SYNTHESIS OF COMPOUNDS LABELLED WITH ISOTOPES
OF CARBON
Synthesis of Isotopically Labelled Nitrogen 1 (4)
Heterocycles
J.E. Clare, K.W.M. Lawrie, C.L. Willis, J.
Yuen
Enzymatic Nucleoside Isotope Exchange an 5 (6)
Alternate Route to [14C]-Labeled HCV
Polymerase Inhibitor
Steve A. de Keczer, Mohammad R. Masjedizadeh
The Synthesis of Isotopically Labelled CETP 11 (4)
Inhibitors
Ryan M. Kelly, Keith E. McCarthy, Sandra A.
Miller, Michael J. Nesler, Klaas
Schildknegt, Carrie B. Wager, Kathleen Zandi
Synthesis of Two C-14 Labeled 15 (4)
Cyclooxygenase-II Inhibitors via a Pummerer
Degradation-Resynthesis Strategy
Charles S. Elmore, Dennis C. Dean, Tina M.
Marks, Matthew P. Braun, Marjorie A. Egan,
David G. Melillo
Different Routes to Carbon-14 Labeled 19 (2)
5-Aryloxy-3-isopropylindols
Dietrich Seidel
Synthesis of [14C2] PD 0326234, A 21 (4)
PPARγAgonist
Yinsheng Zhang, Che C. Huang
The Synthesis of Carbon-14 Labelled Indoles 25 (4)
D. Hendry, N.S. Nixon, B.S. Roughley, P.
Skagestad, P.M. Winton
Synthesis of Carbon-14 Labeled 5HT4 29 (4)
Antagonist R01160367
Mohammad R. Masjedizadeh, Majid Keshavarz
Synthesis of 14C Labelled AZD-3355 33 (4)
Roger Simonsson
SYNTHESIS OF COMPOUNDS LABELLED WITH ISOTOPES
OF HYDROGEN
Isotopic Labeling by Hydrogen Isotope 37 (6)
Exchange: Status and Prospects
Richard Heys
Controlled Polydeuteration of Biologically 43 (4)
Active Polyphenolics
K. W臧舁 S. Rasku, P. Kiuru, K. Parikka,
E. Lepp舁  T. Jokela, A. Salakka, P. Lewis
Tritio-Dehalogenation: New Variants on an Old 47 (4)
Theme
D.J. Wilkinson, M.J. Hickey, L.P. Kingston,
A.N. Mather
Tritium Labelling Studies of SCH 388714 51 (4)
UnderThermal and Microwave Conditions
D. Hesk, M. Calvert, P. McNamara
Tritium Labelling of Aromatic and Aliphatic 55 (4)
Aldehydes using Crabtree's Catalyst,
[Ir(cod)py(PCy 3)]PF 6
M.R. Chappele, A.D. Morgan
Stereospecific C-H Bond Activation for 59 (4)
Deuterium and Tritium Labeling of
Glycoconjugates Conducted in Ultrasonic and
Microwave Fields
E.A. Cioffi, M.L. Cook, K.E. Alston, B.Y. Le
Preparation of Carrier-Free [Methyl-ウH] 63 (4)
Methyl Nosylate and Its Use as a
Radiochemically-Stable Methylating Reagent
S. Pounds
Recent Advances in the Development of 67 (4)
Microwave-Enhanced Radiolabeling Procedures
S.Y. Lu, F.T. Chin, J.A. McCarron, J.R.
Jones, V.W. Pike
Transition Metal Catalyzed Sodium Borotritide 71 (4)
Reductions: A useful Alternative to Tritium
Gas
Y.S. Tang, W. Liu, A. Chaudhary, D.G.
Melillo, D.C. Dean
ADVANCES IN ANALYSIS OF ISOTOPICALLY LABELLED
COMPOUNDS
Assigning the Position of Radiolabelling 75 (4)
within Tritiated Biomolecules by Accurate
Mass using High Performance Liquid
Chromatography-Tandem Mass Spectrometry
Adam Colebrook
Laser Based Carbon-14 Atom Counting for 79 (4)
Biomedical Studies
D.E. Murnick, M. Perez, M. Pulickal
Direct Analysis of Radioisotopes in Complex 83 (4)
Samples by Accelerator Mass Spectrometry
Rosa G. Liberman, Paul L. Skipper, Barbara
J. Hughey, Man H. Choi, John S. Wishnok,
Robert E. Klinkowstein, Ruth E. Shefer,
Shawn Harriman, Chandra Prakash, Steven R.
Tannenbaum
Advances in Radio-HPLC 87 (4)
Dian Y. Lee
GC/MS Determination of Methane [35S] Sulfonyl 91 (4)
Chloride Specific Activity
Allen N. Jones, Dennis C. Dean, Michael A.
Wallace, David G. Melillo
PRODUCTION OF STABLE AND RADIOISOTOPES
Production of Therapeutic Radioisotopes in
the ORNL High Flux Isotope Reactor (HFIR)
F.F. (Russ) Knapp, Jr, S. Mirzadeh,
A.L. Beets, M. Du
Production of Stable Isotopes Utilizing the
Plasma Separation Process
F.J. Tarallo, T.S. Bigelow, N.R.
Stevenson
Recent Progress in the Application of 95 (4)
Extraction Chromatography to Radionuclide
Separations for Nuclear Medicine
M.L. Dietz
Application of Crystalline Inorganic Ion 99 (4)
Exchangers to Medical Radioisotope Generators
Alan Cisar, Todd Adams, Hariprasad Gali,
Teresia M ler, Paul Sylvester
Production of Tungsten-188 in the BR2 Reactor 103 (4)
in Collaboration With ORNL
B. Ponsard, S. Mirzadeh, F.F. (Russ) Knapp,
Jr
Collisionally Assisted Highly Selective Laser
Isotope Separation of Carbon-13
O.V. Boyarkin, M. Kowalczyk, M. Polianski,
T.R. Rizzo
THE ROLE OF ISOTOPES IN PHARMACOKINETICS AND
DRUG METABOLISM
Use of AMS in Ultralow Dose Human Radioactive 107 (4)
Mass Balance Studies
Graham Lappin and R. Colin Garner
The Application of Quantitative Whole Body
Autoradiography to Answer Pivotal Questions
in Drug Discovery
E. Solon
The Oxidative Metabolism of 111 (4)
Cyclopropylamines: Fate of the Three Carbons
and Other Interesting Observations
Robert P. Hanzlik, Shawn P. Harriman,
Christopher L. Shaffer, Yakov M. Koen,
Rheem, A. Totah, Matthew A. Cerny
Radiochemical Tracers: Essential Tools for 115 (6)
Drug Metabolism Studies
Chandra Prakash, Amin Kamel Zhuang Miao
ISOTOPES IN THE SYNTHESIS AND APPLICATION OF
LABELLED MACROMOLECULES
Targeted Radionuclide Imaging Using
Standardized Assembled Complexes.
VEGF-driven Tumor Imaging
Francis G. Blankenberg, Stefanie Mandl,
Yu-An Cao, Caitlin O'Conell-Rodwell,
Christopher Contag, Carina Mari, Timur
I. Gaynutdinov, Jean-Luc Vanderheyden,
Renee Aloise, Marina V. Backer, Joseph
M. Backer
Labelled Polymer Supported Drugs
D. Giribone, A. Pignatti, E. Fontana
The Synthesis of Carbon 14-Labelled PEGs 121 (4)
G.I. Shemilt, R.G. Reid, P.D. Wilde, A.
Mangion
Solid State Isotope Exchange of Hydrogen for 125 (4)
Spillover Tritium in Proteins
Yu. A. Zolotarev, A.K. Dadayan, E.M.
Dorokhova, N N. Vtyurin, V.S. Kozik, Yu. A.
Borisov, N.F. Myasoedov
HANDLING OF ISOTOPES: SAFETY, POLITICAL AND
SOCIAL DIMENSIONS
Protection of the Environment: Assessing
Ionising Radiation Impacts on Non-human
Biota
D. Oughton, J. Brown, C-M. Larsson, P.
Strand
Recovery of Tritium from Tritiated
Pharmaceutical Mixed Wastes for Re-Use: A
Commercial Reality
W.T. Shmayda
NRC Inspections of Materials Licences
Betsy Ullrich
Security Risks of Radioactive Material 129 (4)
Joel Lubenau
APPLICATIONS OF ISOTOPES IN ORGANIC AND
BIOORGANIC REACTION MECHANISMS
Hydrogen Kinetic Isotope Effects in the
Studies of the Mechanism of Action of
L-Tyrosine Phenol Lyase
Marianna Kanska
Isopentenyl Diphosphate Biosynthesis via 133 (4)
1-Deoxyxylulose 5-phosphate
Wolfgang Eisenreich, Felix Rohdich,
Adelbert Bacher
Application of Uniformly Tritium Labeled
Peptides in Studies of Organism's Tissue
Proteinase Activity
Yu. A. Zolotarev, A.K. Dadayan, E.M.
Dorokhova, V.S. Kozik, N.F. Myasoedov
Stereocontrolled Synthesis of Oxygen 137 (4)
Containing Heterocycles
C.S. Barry, J.R. Harding, C.D. King, G.D.
Parker, C.L. Willis
BIOCHEMICAL METHODS FOR PREPARING ISOTOPICALLY
LABELLED COMPOUNDS
Short Review on Application of Biochemical
Methods for the Synthesis of Isotopomers
T. Moenius
Enzymatic Syntheses of Aromatic Amino Acids 141 (4)
Labeled with Carbon and Hydrogen Isotopes
M. Kanska, E. Boroda, W. Augustyniak, R.
Kanski
Bio-synthesis of Stable Isotopes Labelled 145 (4)
Thyroid Hormones Precursor
M. De Meyer, A.L. Hantson, M. Vanthournhout
Synthesis and Use of Radiolabelled Probes for 149 (4)
the Study of Glycosyl Transferases in a
Generalizable Assay System
S.E. Eveland, B. Leiting, K.D. Pryor, S.A.
Hyland, M.S. Anderson
Enzymatic Synthesis of ウイP-Labeled 153 (4)
Nucleotides: Covalent and Reversibly Binding
ligands for Adenylyl Cyclases
R.A. Johnson, I. Shoshani
ADVANCES IN RADIOTRACER IMAGING FOR DRUG
DISCOVERY AND DEVELOPMENT
Development and Application of Amyloid
Imaging Agents for PET
Chester Mathis
In vitro and ex vivo Evaluation of
Potential Beta-Amyloid Radiotracers for PET
Alun Wilson
Is Internalization Responsible for the M2
Selectivity of FP-TZTP?
Laura Ravasi
Imaging in Neuroscience Drug Development
Richard Hargreaves
Receptor-Based Radiotracers for Imaging the 157 (4)
Proliferative Status of Breast Tumors
Robert H. Mach, C. Brown-Proctor, S.
Vangveravong, J.B. Blair, N. Buchheimer, J.
Bottoms, K.T. Wheeler
Acute and Chronic Effects of Drugs on
Receptor Systems
Doris Doudet
APPLICATIONS OF ISOTOPES IN AGRICULTURAL,
NUTRITIONAL AND ENVIRONMENTAL RESEARCH
The Synthesis of 74C Labeled Silthiofam: A 161 (4)
Novel Fungicide for Wheat Take-All Disease
Brad D. Maxwell
Investigations of the Role of Chloroacetic 165 (6)
Acids In Forest Ecosystems Using Carbon 14
and Chlorine 36
M. Matucha, M. Gryndler, H. Uhlirova, S.T.
Forczek, K. Fuksova, P. Schr er
Measuring Bone Resorption with 42-44 Ca, 45
Ca and 41 Ca
C.M. Weaver
Quantifying Human Vitamin Kinetics with AMS
J.S. Vogel, S.R. Deuker, Y. Lin, S.
Hickenbottom, A.J. Clifford
Increase of 14 C-Isofluorate in Mouse Brain
Due to Co-administered Pesticides
B.A. Buchholz, G.A. Keating II, J.S.
Vogel
APPLICATIONS OF ISOTOPES IN PHARMACOLOGICAL,
CLINICAL, AND MEDICAL RESEARCH
A Radioimmunoassay Based on Scintillation 171 (4)
Proximity Technology for the Measurement of
Risedronate in Rat Serum
R.A. Reitman, R.L. Wimalasena, B.D. Keck
Effect of Certain Active Components of 175 (4)
Chinese Medicinal Herbs on Aβ Production
Studied with L- [35S] Methionine
Yaer Hu, Aimin Zongqin Xia
Nonconventional Isotopes in PET Research
Michael J. Welch
Carbon-11 Serotonin Transporter Ligands 179 (4)
M.M. Goodman, C. Plisson, N. Jarkas, J.
McConathy, J R. Votaw, R.J. Volt C.D. Kilts
[18F]4-Fluorobenzyl Iodide as a Useful 183 (4)
Precursor in Pet Research: Application in the
Development of Dopaminergic and Cholinergic
Radiotracers
Robert H. Mach, H.D. Gage, N. Buchheimer,
T.E. Morton, J. Bottoms, R.L. Ehrenkaufer
Radioiodinations via Organoboron Intermediates 187 (4)
G.W. Kabalka, N. Natarajan, A.L. Smith,
M.R. Akula, A.R. Mereddy
APPLICATIONS OF ISOTOPES IN PHARMACEUTICAL
RESEARCH AND DEVELOPMENT
Quantitative Protein-Drug Binding in vivo 191 (4)
D. Hillegonds, M Palmblad, P.G. Grant, G.
Bench, B.A. Buchholz, G.A. Keating, J.S.
Vogel
Synthesis of Aryl [35S] Sulfonamide 195 (4)
Radioligands
Michael Wallace, Conrad Raab, Dennis Dean,
David Melillo
Strategic Outlook: Future Methods in DMPK
and Subsequent Requirements for
Isotopically Labelled Compounds
Jochen Maas, Volker Krone
Using Stable Isotopes with Mass
Spectrometry and Chemiluminescent Nitrogen
Detection to Accelerate Early Stage Drug
Discovery
Gavin Dollinger
The Role of AMS in Ultralow Dose Clinical 199 (4)
Drug Metabolism Studies (Microdosing) - Uses
in Early Drug Development
Graham Lappin, R. Colin Garner
Poster Sessions
[ウH]- and [14C]-RO0275646, A Vitamin D 203 (4)
Analog
S-Y. Wu, S.A. De Keczer, M.R.
Masjedizadeh
Martin D. Kamen (1913-2002), Co-Discoverer 207 (4)
of Carbon-14
C.N. Filer
Parallel Optimisation of Hydrogen Isotope 211 (4)
Exchange Mediated by Homogeneous Catalysts.
A Collaboration Between the Isotope Groups
at Astra Zeneca R&D Molndal and Charnwood
Goran N. Nilsson, Roger Simonsson, Dave
J. Wilkinson
Synthesis of Radio and Stable Labelled 215 (4)
Derivatives of Novel Glycine Antagonists
M. Almi
Vibrational Analysis and Infrared Spectra 219 (4)
of N[1-*C]Capronyl-N'- Phenylthiourea
(*C:ケイC,ケウC,14C) Using Computational
Chemistry
C.A. Simion
N-[1-14C] Palmitoyl-N'-Phenylurea. 223 (4)
Synthesis and General Characterization
C.A. Simion, I. Bally, C.M. Barna
Isotopic Labelling of 227 (4)
MicrosomalTriglycerideTransfer Protein
(MTP) Inhibitor BMS-201038
M.D. Ogan, M. Lago, J.K. Rinehart
Hydrogen Kinetic Isotope Effects in the 231 (4)
Studies of the Mechanism of Action of
L-Tyrosine Phenol Lyase
W. Augustyniak, R. Kanski, M. Kanska
Syntheses of Carbon and Hydrogen 235 (4)
Isotopomers of L-Tyrosine
W. Augustyniak, P. Suchecki, R. Kanski,
M. Kanska
Synthesis of 5'-Hydroxy-L-Tryptophan 239 (4)
Labeled with Carbon-14, Deuterium and
Tritium
E. Boroda, M. Karriska, R. Kanski
Pharmacokinetic Studies of Stable
Isotope Labeled Methionine in Folate-,
Choline- and Pyridoxine-Deficient Rats
Y. Shinohara, K. Ogawa, H. Hasegawa, T.
Hashimoto
Evaluation of 11β-HSD Activities
in vivo Following Oral Administration
of Cortisol-13 C 4, 2 H1 to a Human
Subject
Y. Kasuya, A. Yokokawa, S. Takayama, H.
Shibasaki, T. Furuta
Mercuration/lododemercuration: A Practical 243 (2)
Approach for the Rapid Preparation of
Iodinated Labelling Precursors
M.J. Hickey, L.P. Kingston, J.R. Jones,
W.J.S. Lockley, A.N. Mather, D.J.
Wilkinson
Deuterium Labelling with 245 (2)
Cycloocta-1,5-dienyliridium(I),
1,1,1,5,5,5-hexafluoropentan-2,4-dionate.
Comparison of D20 and D2 Donors
M.J. Hickey, L.P. Kingston, J.R. Jones,
W.J.S. Lockley, A.N. Mather, B.M.
McAuley, D.J. Wilkinson
Purification and Characterization of 247 (4)
Radioiodinated Insulin Using LC/MS and
Peptide Mapping
Dean K. Clodfelter, Melvin G. Johnson,
W.E. Legan, Tamara R. Priest, Michael
C. Spence
Radiosynthesis Conducted Under cGMP 251 (4)
Compliance
Cindy Lloyd, Jeannette Potwin,
Christopher Wright
Ultrasonic Particle Size Reduction 255 (2)
David J. Schenk, Allen N. Jones,
Matthew P. Braun, Dennis C. Dean, David
G. Melillo
A Method for the Carbon-13 Labeling of 257 (2)
Pyrazinones
Jonathan Z. Ho, Matthew P. Braun,
Dennis C. Dean, David G. Melillo
Synthesis of Duloxetine Metabolites and 259 (4)
their Deuterium Labeled Analogs: I.
Preparation of the Key 1-Fluoronaphthalene
Derivatives
Fengjiun Kuo, William J. Wheeler
Synthesis of Duloxetine Metabolites and 263 (4)
their Deuterium Labeled Analogs: II:
Preparation of Phase I and II Metabolites
F. Kuo, T.A. Gillespie, P. Kulanthaive%
F.J. Lantz, J.W. Ma, D.L.G. Nelson,
P.G. Threldkeld, W.J. Wheeler, M.
Zmijewski
I. Synthesis of LY455169-[イH2], A Model 267 (4)
Study for Tritium Labeling of LY-459477.
II. Synthesis of LY459477-[ウH2]
Fengjiun Kuo, Palaniappan Kulanthaivel
Gregory A. Rener, William, J. Wheeler,
Ping Yi
Synthesis of LY333531-[14C] MsOH, a PKC 271 (4)
β Inhibitor and Its Use in QWBA
Studies in Rats
Douglas D. O'Bannon, Sylvia H. Chay,
Jennifer L. Herman, Carlos O. Garner,
Barry C. Peterson
A Study of the Synthesis of 275 (4)
2-Fluorobenzonitrile-[cyano-14C], a Key
Intermediate in the Synthesis of
Radiolabeled LY293111 NA, a Multiple
Eicosanoid Pathway Modulator
Douglas D.O. Bannon, William J. Wheeler
A Robust Method for theTritiation of 279 (2)
N-(2,4-dichlorobenzoyl)-4-Methoxybenzenesulf
onamide (LY573629)
Eli A. Stoddard
A Novel Method for the Synthesis of 281 (4)
Isotopically Labeled Substituted Indoles
and (satins
Eli A. Stoddard, William J. Wheeler
Tritium Labeling of a Class of 285 (4)
Spirooxindolamines Possessing Analgesic
Properties
Peter Str , Jonas Malmquist, Jonas
Hansson, Ulrika Yngve, Alf Claesson
The Use of LC/MS to Identify Unknown 289 (4)
Radioactive Impurities in Clinical Tracers
A.N. Jones, M. Braun, D. Dean, C.
Elmore, Y. Jakubowski, H. Jenkins, D.
Melillo, R. Miller, S. Staskiewicz, M.
Wallace
Highly Sensitive 14C and ウH Quantification 293 (4)
of Biochemical Samples Using Accelerator
Mass Spectrometry
T.J. Ognibene and J.S. Vogel
Synthesis of Isotopomers of the MHC II 297 (4)
Antagonist AZD2315
H. Booth, J.R. Harding. D.P. Woodhouse
Synthesis of Isotopomers of Gefitinib 301 (4)
J.A. Bergin, H. Booth, N. Bushby J.R.
Harding, D.A. Killick. C.D. King, D.J.
Wilkinson
A Radiolabeled Synthesis of [Indole-C-14] 305 (4)
LY317615, a PKC Inhibitor
John W. Kennington, Jr., Douglas D.
O'Bannon
The Synthesis of [14C]CP-331,684 309 (4)
Michael R. Collins, Keith E. McCarthy,
Kathieen S. Zandi
The Preparation of the P2 Receptor Agonist 313 (4)
2-[Methyl-ウH]
Methylthioadenosine-5'-Diphosphate
Michael R. Chappele, Calvin R. Hawes
Design and Application of Stable or 317 (4)
Radiolabelled Carbamates
S.L. Kitson
Titanium Molybdate Gel as 99Mo/99mTc 321 (4)
Generator Matrix
F. Monroy-Guzm疣, O. Cort駸 Romero, L.
Longoria, T. Martinez Castillo
Synthesis Installation of 325 (6)
Zirconium-99Molybdate Gels to 99Mo/99Tc
Generators
Fabiola Monroy-Guzman, Edna Selene
Barron Santos, Sabino Hernandez
Synthesis of [Ring -14C(U)] 331 (2)
Ortho-Sulfobenzoic Acid
C.T. Peng, Steven McClain
Synthesis of 14C-Labelled Flumetralin
in Two Different Aromatic Positions
Hyun-II Shin, In-HaeYe, Young-Seok Kim,
Ki-Seung Lee, Won-Hun Ham
Use of Fluorous Electrophiles as Scavengers 333 (4)
for Excess Amine in the Preparation of
Sulfur-35 Labeled Radioligands
Andy Shiqiang Zhang, Charles S. Elmore,
MarjorieA. Egan, David G. Melillo,
Dennis C. Dean
Synthesis of Carbon-14 and Stable Labelled 337 (4)
NN414: A Potent Potassium Channel Opener
Steen K. Johansen, Jesper B.
Kristensen, Lars K. M ler, Claus U.
Jessen, Christian Foged
Microwaves: Applications to Isotope 341 (4)
Labelled Compound Preparations
Danilo Giribone, Chiara Felicini,
Alberto Pignatti, Ermina Fontana
Labelled Polymer Supported Drugs 345 (4)
Danilo Giribone, Alberto Pignatti,
Ermina Fontana
An Efficient Synthesis of [2-14C] Ethyl 349 (4)
Nipecotate
Giliyar Ullas, Terry Kelly
The Synthesis of Neutrophil Elastase 353 (4)
Inhibitor LY544349-[2H4] and its Metabolite
LY575481-[2H4]
Cheryl S. Mattingly, Boris A. Czeskis,
WilliamJ. Wheeler
Strattera (Atomoxetine HCL), an Inhibitor
of the NorephinephrineTransporter
1.The Preparation of C-14 Labeled
Atomoxetine and Two of its Metabolites
2. The Preparation and Biological 357 (4)
Evaluation of Some Additional Putative
Metabolites of Atomoxetine
William J. Wheeler, Franklin P.
Bymaster, David O. Calligaro, Preston
C. Conrad, Perry C. Heath, Fengjiun
Kuo, John M. McGill, Robert E. Murff,
John-Michael Sauer, David T. Wong
Synthesis of Vedaclidine-[14C](+)- 361 (4)
Tartrate, A Centrally Acting Muscarinic
Agonist and Its Use in QWBA Studies in Rats
William J. Wheeler, Douglas D.O Bannon,
Sylvia H. Chay, Jennifer L. Herman
The Synthesis of C-14 and Tritium Labeled 365 (4)
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrol
o[2,3-d]pyrimidin-5-yl)ethyl]
benzoyl]-L-Glutamic Acid, Disodium Salt
(LY231514錨iNa, ALIMTAョ Pemetrexed Disodium)
Douglas D. O'Bannon, William J.
Wheeler, Barry C. Peterson
Synthesis,Tissue Distribution and Recovery 369 (4)
of 14C Labeled αv β3 Inhibtors
Chandra B. Gamlath, Bradley R.
McKinnis, Lesley A. Albin, Lori J.
Kraus, Jeffery L. Keene, Kathy J. Hotz,
Matt R. Liley, Melissa K. Lantz, Peter
G. Ruminski, Thomas E. Rogers
Preparation of Tritiated Hemiasterlins 373 (4)
Albert Minnick, Arie Zask, Joshua
Kaplan, Frank Koehn, Michael May
Synthesis of Thyroid Hormones Labelled with 377 (4)
Carbon-13
M. De Meyer, N. Gu駻it, A.L. Hantson
Development and Application of aTritium 381 (4)
Cryo-Probe: ウH NMR Studies at the
Microcurie Level of Radioactivity
J.P. Bloxsidge, R.N. Garman, D.G.
Gilles, J.R. Jones, S-Y. Lu
Synthesis of LY335979-[Piperazine-14C] 385 (4)
Franklin H. White, Dean K. Clodfelter
Synthesis of a Stable Labeled Metabolite of 389 (4)
LY582563
Franklin H. White, Peter Kowalenko
Synthesis of Labeled LY504132, a Selective 393 (4)
Estrogen Receptor Modulator
R. Aleks Davis, William J. Wheeler,
Franklin H. White
Synthesis of Deuterium Labelled Metabolites 397 (2)
of Plant Lignans
Eija Lepp舁 Kristiina W臧舁 
Deuterolabeling Methods for Alkylresorcinols 399 (2)

K. Parikka, K. W臧舁 
The Synthesis of the Tritium, C-14 and 401 (4)
Stable Labeled Isotopomers of
2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylet
hoxy)phenoxy] benzo-[b] thiophen-6-ol
Hydrochloride Salt (LY353381, Arzoxifene)
and the Stable Labeled Isotopomer of its
O-Des-Methyl Metabolite (LY335562)
Michael C. Spence, Ronald J. Lantz,
Thomas J. Lindsay, William J. Wheeler,
Tony Y. Zhang, Fengjiun Kuo
Stable Isotope Enrichment Measurements by 405 (4)
Mass Spectrometry (MS): Effect of an
Electrochemical Reaction to MS Ion Intensity
A. Wu, B. Markus, A.J. Allentoff, T. Ray
Enzymatic Hydrolysis of LAF389 409 (4)
Kirk Bordeaux, Tapan Ray
Synthesis of Radio- and Stable-Labeled
Fasidotril
Tapan Ray, Grazyna Ciszewska, Alban J.
Allentoff, Amy Wu, Lawrence Jones
Synthesis and Tissue Distribution of 413 (4)
14C-Nonpeptide αvβ3 Antagonists
Bradley R. McKinnis, Lesley A. Albin,
James P. Doom, Alan F. Gasiecki, Kathy
J. Hotz, Jeffery L. Keene, Ish K.
Khanna, Lori J. Kraus, Matt R. Liley,
John J. Likos, Srinivasan Nagarajan,
Thomas E. Rogers, Rajendra K. Singh
Rapid Synthesis of High Specific 417 (4)
ActivityTritium-Labeled Antiobiotics
Scot Pounds
Synthesis of a Sulfur-35 Labeled Potassium 421 (4)
Channel IKr Radioligand
Conrad E. Raab, John W. Butcher, Thomas
M Connolly, Jerzy Karczewski, Nathan X.
Yu, Steven J. Staskiewicz, Nigel
Liverton, Dennis C. Dean, David G.
Melillo
Synthesis of aTritium Labeled GnRH Receptor 425 (4)
Antagonist
Ashok Chaudhary, Yui Tang, Dennis Dean,
Wallace Ashton, David Melillo
Synthesis of 429 (4)
[3,5-Dichlorobenzenesulfonamide-U-14C]
Labeled VLA-4 Antagonists
Nathan X Yu, Conrad E. Raab, Dennis C.
Dean, David G. Melillo
Carbon-14 Labeling of Anti-Ulcerative Drug, 433 (2)
IY-811492
Sung W. Rhee, Mary J. Tanga, Chang-Bae
Jin, Dong-Hyun Kim, Seung-Mock Lee
CerOx Cost-Effective Treatment of Organic 435 (4)
Hazardous Waste/Mixed Waste with a Safe,
Non-thermal, RCRA Exempt System
A.M. Harris, S.L. Nolan, N. Nelson
Tuftsin and Dihydroprogesterone
Analysis in Human Plasma via an
Isotopic Dilution Method withTritium
Labeled Analogs
I. Yu Nagaev, V.P. Shevchenko, K.V.
Shevchenko, N.F Myasoedov, A. Susan
The Synthesis of Tritium-Labelled
Biologically Active Compounds via
Selective Solid-Phase Hydrogenolysis
and Hydrogenation
V.P. Shevchenko, I. Yu Nagaev, N.F.
Myasoedov, A. Susan
Solid-PhaseTritiation of Compounds
Otherwise Labile in Reactions with
Tritium Gas
V.P. Shevchenko, I. Yu Nagaev, N.F.
Myasoedov, A.B. Susan
Current Status for Applications of
Hydrophobic Pt-Catalysts in Hydrogen
Isotopes Enrichment
Gh. Ionita, Irina Popescu, M. Gluga, I.
Stefanescu, D-Tru Steflea
Iridium-Catalyzed Direct Tritium Labeling: 439 (4)
Synthesis of a Tritium Labeled CCR-3
Inhibitor
A.J. Allentoff, A. Wu, T. Ray
Limiting Oxidation when Labeling with 125I 443 (4)
Lactoperoxidase, IODO-GENOョ, and
Chloramine-T HPLC Tests on Peptides
Containing Methionine
Garth Brown, Zakos Pallikaros, Scott
Palmer, Arvind Patel
The Application of Fast Isotopic Tritium 447 (4)
Labeling Techniques to Bridge the Gap in
Drug Discovery and Development
W.T. Stolle, J.A. Easter, Z. Jian, V.K.
Mahindroo, B.D. Maxwell, M.B. Skaddan
A Case Study of Microwave Deuterations of 451 (2)
Estrone
P. Kiuru, K. W臧舁 
The Synthesis of Labeled 453 (10)

3'-Azido-3'-Deoxythymidine Derivatives

Displaying Anti-HIV Activity

G.V. Sidorov, Yu B. Zverkov, N.F.

Myasoedov, I.L. Karpenko, E.A.

Shirokova, D.M. Yanvarev, M.V. Yasko,

Yu. S. Skoblov, A.B. Susan

Synthesis of [ケウC6] BMS-275183, An Orally 463 (4)

Bioavailable Taxane for Use in Clinical

Evaluation

M.D. Ogan, J. Kadow, J.K. Rinehart

Advances in Preparative 467 (2)

Radiochromatography: Evaluation of a New

HPLC Radioactive Detector

D.C. Hoerr, S.D. Shulman, M. Combs, T.

Oikari

Preparation of Carrier-Free[Methyl-3H] 469 (4)

Methyl Nosylate And Its Use As A

Radiochemically-Stable Methylating Reagent

Scott Pounds

Synthesis of Carbon-14 labeled Sch 351125, 473 (4)

A CCR5 receptor antagonist

Sumei Ren, P. Rollin, P. McNamara, J.

Lee, S. Saluja, D. Koharski, S.

Hendershot, V. Truong

Use of Isotopic Tracers for Measuring 477 (6)

Calcium Metabolism in Humans

Connie Marie Weaver

Production and Clinical Properties of 483 (4)

Europium-152 in RadioisotopeTeletherapy

S.L.v. Adelman, Jane C. Bowden v.

Adelman

Author Index 487 (4)

Keyword Index 491