Advances in Ion Mobility-Mass Spectrometry : Fundamentals, Instrumentation and Applications (Comprehensive Analytical Chemistry)

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Advances in Ion Mobility-Mass Spectrometry : Fundamentals, Instrumentation and Applications (Comprehensive Analytical Chemistry)

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  • 製本 Hardcover:ハードカバー版/ページ数 264 p.
  • 言語 ENG,ENG
  • 商品コード 9780444641540
  • DDC分類 543

Full Description


Ion Mobility Spectrometry, Volume 83 will focuses on new trends, methods and instrumentation in the field, starting from the innovations of each technique, to the most progressive challenges of IM-MS. Chapters includes section on Recent advances in IM-MS, IM-MS Principles and Theory, IM-MS Applications and Instrumentation, and the Future of IM-MS.

Table of Contents

Contributors to Volume 83                          ix
Series Editor's Preface xi
Preface xiii
1 Modelling Collisional Cross Sections 1 (22)
James S. Prell
1 Introduction 1 (3)
2 Projection Approximation 4 (6)
3 Projected Superposition Approximation 10 (2)
and Local Collision Probability
Approximation
4 Exact Hard-Spheres Scattering 12 (2)
5 Trajectory Method 14 (4)
6 Conclusions and Outlook 18 (1)
References 19 (4)
2 Tandem Mobility Spectrometry at Ambient 23 (28)
Pressure
G.A. Eiceman
G. Lee
M. Menlyadiev
P.E. Fowler
D. Pasupuleti
S. Holopainen
U. Chiluwal
H. Shokri
1 Introduction 23 (4)
2 Tandem DMS/IMS2 27 (6)
3 Tandem FAIMS-IMS (MS) 33 (1)
4 Reactive Stages for Tandem Mobility 34 (2)
Spectrometry
5 Tandem Differential Mobility 36 (6)
Spectrometry
6 Tandem Ion Mobility Spectrometry at 42 (5)
Ambient Pressure
References 47 (4)
3 Ion-Mobility Mass Spectrometry for Chiral 51 (32)
Analysis of Small Molecules
J. Diana Zhang
K.M. Mohibul Kabir
W. Alexander Donald
1 Introduction 51 (2)
2 Mass Spectrometry for Chiral 53 (6)
Discrimination
3 Ion-Mobility Spectrometry for Chiral 59 (19)
Discrimination
4 Conclusions 78 (1)
References 79 (4)
4 Dynamic Clustering and Ion Microsolvation 83 (40)
W. Scott Hopkins
1 Introduction 83 (1)
2 The Effect of the Asymmetric Field 84 (22)
3 Using DMS Clustering Behaviour to 106 (12)
Assess Molecular Properties
Acknowledgements 118 (1)
References 118 (5)
5 Ion Mobility-Mass Spectrometry in 123 (38)
Metabolomic, Lipidomic, and Proteomic
Analyses
Christopher D. Chouinard
Gabe Nagy
Richard D. Smith
Erin S. Baker
1 Introduction 124 (2)
2 Ion Mobility-Mass Spectrometry in 126 (10)
Metabolomics and Lipidomics
3 Ion Mobility-Mass Spectrometry in 136 (5)
Proteomics
4 The Future Outlook for IMS-MS in the 141 (5)
Omics
5 Conclusions 146 (1)
References 146 (15)
6 Ion Mobility in Structural Biology 161 (36)
Timothy M. Allison
Michael Landreh
1 Introduction 161 (3)
2 Structural Aspects of Proteins in the 164 (3)
Gas Phase
3 Instrumentation 167 (4)
4 IM for CCS Determination 171 (5)
5 Using IM-MS to Study Protein Folding in 176 (2)
the Gas Phase
6 Complementary and Supporting 178 (4)
Computational Resources
7 IM for Separation 182 (2)
8 Combining IM-MS With Other Structure 184 (3)
Analysis Methods
9 Conclusions 187 (1)
References 187 (10)
7 IM-MS for Supramolecular Systems: 197 (40)
Structures and Dynamics of Noncovalent
Complexes From Solution to Gas Phase
Tae Su Choi
Jongcheol Seo
Hugh I. Kim
1 Introduction 197 (2)
2 Structural Analysis Based on CCS 199 (1)
Measurements Using ESI-IM-MS
3 ESI-IM-MS for Host-Guest Complexes With 199 (12)
Synthetic Receptors
4 ESI-IM-MS for Noncovalent Biomolecular 211 (13)
Complexes
5 Macroprotein Complexes 224 (6)
6 Concluding Remarks 230 (1)
References 231 (6)
8 Ion Mobility Separation Mass Spectrometry 237 (22)
Imaging
Marten F. Snel
1 Introduction 237 (1)
2 Introduction to MS Imaging 238 (4)
3 Initial IMS-MSI Experiments 242 (1)
4 Instrumentation 242 (5)
5 Applications of Ion Mobility Imaging 247 (3)
6 IMS-MSI a Worked Example 250 (4)
7 Conclusions and Future Perspectives 254 (1)
References 254 (5)
Index 259