Full Description
Introduction to Nuclear Mechanics and Genome Regulation provides a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, this book will be an invaluable reference for students, researchers and clinicians looking to understand this area of cutting-edge study.
Contents
1. Physico-chemical constraints in DNA2. 3D organization of chromosomes and functional gene clusters3. Spatial dimension to DNA transcription, replication, damage and repair4. Dynamics within the nucleus and functional microrheology5. Cytoskeleton to nuclear links and prestressed nuclear architecture6. Nuclear mechanotransduction and genetic networks7. Chromatin plasticity during differentiation, development and reprogramming8. Mechanical homeostasis of the nucleus during cell division and migration9. Nuclear mechanics in diseases and as diagnostic markers10. Evolutionary constraints in DNA packing and genome regulation
