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Full Description
Long Noncoding RNAsoverview of the state-of-the-art methods in the field that have created an understanding of the sequence, structure, function and disease associations of lncRNAs. The decade following the availability of the reference human genome has seen tremendous advancements in the scale and throughput of nucleotide sequencing and its widespread application. This sequencing technology has allowed for rapid, advanced study of the functionalities of lncRNAs and has revealed their intricate and important roles in a variety of biological processes and pathophysiology of diseases.
Contents
1. Introduction 2. Methods for discovery and annotation of long noncoding RNA 3. Long noncoding RNAs in model organisms 4. Databases and resources of long noncoding RNAs 5. Conservation and variation in lncRNAs 6. Disease associations of lncRNAs 7. Molecular dissection of lncRNA function 8. Methods to understand lncRNA function 9. LncRNAs as potential disease biomarkers and drug targets