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Full Description
"ABC Proteins" is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Its key features include: Phylogeny and Evolution of ABC Transporters; Fundamental Aspects of the Mechanism of Action of ABC Transporters; Prokaryote ABC Transporters; Non-Mammalian Transporters; Multidrug Transporters; ABC Transporters, Physiological Roles and Human Disease; and full color throughout.
Contents
Preface. Introduction. PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERS Phylogenetic and Functional Classification of ABC (ATP-binding cassette) Systems Membrane Topology of the Human ABC Transporter Proteins Human and Drosophila ABC-Proteins PART 2-FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC-TRANSPORTERS Structure and Modular Organization of ABC-Transporters Substrate Binding Sites in ABC-Transporters Probing of Conformational Changes,Catalytic Cycle and ABC-Transporters Function X-ray Structure of an Intact ABC-Transporter, MsbA PART 3-PROKARYOTE ABC-TRANSPORTERS Introduction to Bacterial ABC-Transport Systems Import of Solutes by ABC-Transporters-The Maltose System Crystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their Function Bacterial ABC-Transporters Involved in Protein Translocation Bacterial Multidrug Resistance Mediated by ABC-Transporters Structure and Function of Osmoregulated ABC Transporters PART 4 -NON-MAMMALIAN EUKARYOTE ABC-TRANSPORTERS Inventory & Evolution of Fungal ABC Protein Genes. Fungal ABC Proteins in Clinical Drug Resistance & Cellular Detoxification Drug Resistance Mediated by ABC Transporters in Parasites of Humans The Plant ABC Transporter Superfamily: the Functions of a Few and Identities of Many PART 5-MAMMALIAN MULTIDRUG RESISTANCE ABC-TRANSPORTERS Solving the Problem of Multidrug Resistance: ABC Transporters in Clinical Oncology Multidrug Resistance Protein 1 (ABCC1) MRP2, the Apical Export Pump for Anionic Conjugates The Multidrug Resistance Proteins 3-7 Lipid Transport by ABC Transporters Role of ABCA1 in Cell Turnover and Lipid Homeostasis Peroxisome ABC-Transporters ABC-Transporters in Mitochondria The Transporter Associated with Antigen Processing (TAP): A Peptide Transport and Loading Complex Essential for Cellular Immune Responses The Sulphonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel Regulator ABC-Transporters and Human Eye Disease Structure Function Analysis of CFTR
