Description
Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target.
Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study.
- Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathology
- Offers extended coverage of the mechanisms that mediate autophagy
- Covers the role of autophagy in stem cells and induced pluripotent stem cells, as well as the regenerative process of paligenosis
- Highlights important questions that remain to be addressed
Table of Contents
Section I - Overview 1. Introduction Beverly A. Rothermel and Abhinav Diwan 2. Mechanisms of autophagy: the machinery of macroautophagy and points of control Congcong He 3. Regulation of autophagy - transcriptional, posttranscriptional, translational, and posttranslational mechanisms Logan Slade and Thomas Pulinilkunnil 4. Selectivity and trafficking of autophagic cargoes Nuzhat Ahsan, Kautilya Kumar Jena, Subhash 5. The role of lysosomes in autophagy Yoana Rabanal-Ruiz and Viktor I. Korolchuk 6. Methods for measuring autophagy Allen Andres 7. Effects of physiologic inputs on autophagy Tobias Eisenberg, Mahmoud Abdellatif, Senka Ljubojevic-Holzer and Simon SedejSection II - Development 8. Autophagy in germ cells, stem cells, and induced pluripotent stem cells Moydul Islam, Ngoc Uyen Nhi Nguyen, Abhinav Diwan and Beverly A. Rothermel 9. Role of autophagy in embryogenesis Takayuki Tatsumi and Satoshi Tsukamoto 10. Autophagy in hematopoiesis and leukemogenesis Angela Ianniciello and G. Vignir Helgason 11. Autophagy in cell plasticity with particular focus on paligenosis Megan D. Radyk, Lillian B. Spatz and Jason C. MillsSection III - Metabolic control and diabetes 12. Autophagy in the liver Mark Li and Ling Yang 13. Autophagy in adipose tissue Vishaka Vinod and Sihem Boudina 14. Autophagy in the pancreas Amelia Williams, Merilin Georgiou and Catherine Arden 15. Skeletal muscle Greg R. Markby and Kei SakamotoSection IV – Cardiovascular System 16. Autophagy in the cardiovascular system Daniel Peñ-Oyarzún, Valeria Garrido-Moreno, Luis Garrido-Olivares, Ramon Corbalan, Alfredo Criollo and Sergio Lavandero 17. Lungs Poornima Mahavadi, Martina Korfei and Andreas Guenther 18. Autophagy in the vasculature Bieke Steenput, Cédric HG. Neutel, Nina Hermans, Wim Martinet, Guido R.Y. De Meyer, Pieter-Jan Guns and Lynn RothSection V - The nervous system and neurodegeneration 19. Altered autophagy on the path to Parkinson's disease Irene Sanchez-Mirasierra, Sergio Hernandez-Diaz, Saurav Ghimire, Patrick Main and Sandra-Fausia Soukup 20. Autophagic processes in early- and late-onset Alzheimer's disease Chenglong Xie, Yahyah Aman, Johannes Frank, Maria Jose Donate-Lagartos, Ruben Gudmundsrud, Katerina Cechová, Liu Shi, Martin Vyhnalek and Evandro F. FangSection VI – Homeostasis and disease in other organ systems 21. Autophagy as an integral immune system component Elizabeth Bueno, Samuel Wyatt, Robyn Duttenhefner, Daniel Asa, Srinivasulu Dasanna and Sangita C. Sinha 22. Autophagy in the gastrointestinal system and cross talk with microbiota Felipe X. Pimentel-Muiños 23. Role of autophagy in building and maintaining the skeletal system Olivier Camuzard, Marie-Charlotte Trojani, Georges F. Carle and Vale´rie Pierrefite-Carle 24. Autophagy on the road to longevity and aging Maria Manifava and Nicholas T. Ktistakis 25. Autophagy in cancer: friend or foe? Silvia Vega-Rubín-de-Celis 26. Mammalian microautophagy: mechanism and roles in disease Takahiro Seki and Hiroshi Katsuki 27. Chaperone-mediated autophagy - mechanisms and disease role Amelina Albornoz, Alvaro Sequeida, Christian Rodríguez and Mauricio Budini 28. Targeting autophagy: lifestyle and pharmacological approaches Alfredo Briones-Herrera, Tania Gómez-Sierra, Elena Martínez-Klimova, Belén Bellido and José Pedraza-Chaverr
