Description
Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.
Table of Contents
Part I: Role of Translation Factors1. Regulation of Protein Synthesis by eIF4E in the BrainKleanthi Chalkiadaki, Stella Kouloulia, Clive R. Bramham, and Christos G. Gkogkas2. Translational Control Through the eIF4E Binding Proteins in the BrainArgel Aguilar-Valles, Edna Matta-Camacho, and Nahum Sonenberg3. The Integrated Stress Response in Memory and Cognitive DisordersJacqunae L. Mays and Mauro Costa-Mattioli4. The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal FunctionElham Taha and Kobi Rosenblum5. Sidekick No More: Neural Translation Control by p70 ribosomal S6 kinase 1Aditi BhattacharyaPart II: Role of Specific Elements in the mRNA6. Dendritic Targeting and Regulatory RNA Control of Local Neuronal TranslationTaesun Eom, Ilham A. Muslimov, Anna Iacoangeli, and Henri Tiedge7. Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein SynthesisMartin Holcik8. RNA Modifications in the Central Nervous SystemDan Ohtan Wang9. Role of CPEB-Family Proteins in MemoryKausik Si10. FMRP and MicroRNAs in Neuronal Protein SynthesisMonica C. Lannom and Stephanie Ceman11. Focusing on mRNA Granules and Stalled Polysomes Amidst Diverse Mechanisms Underlying mRNA Transport, mRNA Storage and Local TranslationMina N. Anadolu and Wayne S. SossinPart III: Physiological Roles of Translation12. Protein Synthesis and Synapse Specificity in Functional PlasticityRadha Raghuraman, Amrita Benoy, and Sreedharan Sajikumar13. Regulation of Synaptic Homeostasis by Translational MechanismsMegumi Mori, Jay Penney, and Pejmun Haghighi14. Multiple Roles of RNA Regulatory Factors in Neuronal Development and Function in C. elegansMatthew G. Andrusiak and Yishi Jin15. Regulation of mRNA Translation in AxonsPriyanka Patel, Pabitra K. Sahoo, Amar N. Kar, and Jeffery L. Twiss16. Protein Synthesis and Translational Control in Neural Stem Cell Development and NeurogenesisLamees Mohammad, Joscelyn Wiseman, Sarah Erickson, and Guang YangPart IV: Neuronal Protein Synthesis and Disease17. Translational Controls in PainSarah Loerch, June Bryan De La Peña, Jane Song, Joseph J. Pancrazio, Theodore J. Price, and Zachary T. Campbell18. Dysregulated Translation in Autism Spectrum DisorderEmanuela Santini and Anders Borgkvist19. Neuronal mRNA Translation in AddictionEmma Puighermanal and Emmanuel Valjent20. Dysregulated Protein Synthesis in Major Depression DisorderChelcie F. Heaney and Kimberly F. Raab-Graham21. Dysregulation of Neuronal Protein Synthesis in Alzheimer's DiseaseTao Ma22. RNA-Binding Proteins and Translation in Neurodegenerative DiseaseKent E. Duncan23. Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter DiseaseTruus E. M. Abbink, Lisanne E. Wisse, Xuemin Wang, and Christopher G. ProudIndex
