Description
Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.- Covers emerging pharmaceutical and diagnostic applications, including exosomes being tested as carriers of anticancer drugs, ongoing clinical trials, and exosomes as imaging agents for cancer diagnosis and treatment- Brings together a team of highly regarded international authors who provide a full-rounded analysis- Presents comprehensive coverage of the unique biophysical properties of exosomes- Explores current and future possibilities
Table of Contents
1. Introduction to Exosomes in Cancer2. Extracellular Vesicle Biogenesis in Cancer3. Composition, Physicochemical and Biological properties of Exosomes Secreted from Cancer Cells4. Heterogeneity of Tumor Exosomes – Role in Personalized Medicine5. Proteomic Profiling of Tumor Exosomes6. Nucleic Acid Profiling in Exosomes7. Nanotechnology Platforms for Cancer Exosome Analyses8. Microfluidics and Tumor Exosomes9. Exosomal RNA as Biomarkers: Role in Cancer Prevention10. Diagnostic Potential of Tumor Exosomes11. Biodistribution of Tumor Derived Exosomes12. Tumor-Derived Exosomes as Vehicles Mediating Immune Suppression in Cancer13. Exosome Uptake and Cellular Reprogramming in the Tumor Microenvironment14. Exosomes and Intercellular Conduits: Communication between Tumor Cells and Fibroblasts in the Microenvironment15. Exosomes in Tumor Angiogenesis16. Role of Exosomes in Development of Pre-Metastatic Niche17. Role of Exosomes in Tumor Metastasis18. Exosomes and Tumor Drug Resistance19. Exosomes in Cancer Immunotherapy20. Extracellular Vesicles as Vehicles of B Cell Antigen Presentation: Implications for Cancer Vaccine Therapies21. Translational Potential of Tumor Exosomes in Diagnosis and Therapy22. Perspective on Cancer Exosomes in the Future
