Description
Cobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was, however, based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently, the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet, environment and diseases. Conditions like aging, diet and drugs increase the risk of developing cobalamin deficiency, probably because of diminished ability to liberate, absorb or distribute the food-derived vitamin. From a basic science point of view, understanding of the transport and function of the vitamin, may pave the road for using this system for drug delivery.
This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifaceted aspects of the vitamin in health and disease conditions. The book has been written by leading scientists who have significant contributions in this field and represents therefore, a timely unique encyclopaedia on cobalamin.
Table of Contents
Milestones in the Discovery of Pernicious Anemia and Its Treatment
Jörn Schneede
Nutritional and Biochemical Aspects of Cobalamin throughout LifeEva Greibe
Intracellular Processing and Utilization of Cobalamins
Luciana Hannibal and Donald W. Jacobsen
Inherited Defects of Cobalamin Metabolism
David Watkins and David S. Rosenblatt
Conditions and Diseases that Cause Vitamin B12 Deficiency: Form Metabolism to Diseases
Emmanuel Andrès
Vitamin B12 Deficiency in Developing and Newly Industrialising Countries
Chittaranjan Yajnik, Urmila Deshmukh, Prachi Katre and Tejas Limaye
Vitamin B12 in Neurology and Aging
Andrew McCaddon and Joshua W Miller
The Role of Cobalamin in the Central and Peripheral Nervous Systems: Mechanistic Insights
Elena Mutti
Laboratory Markers and Diagnosis of Cobalamin Deficiency
Rima Obeid
Cobalamin during Pregnancy and Lactation
Rima Obeid, Pol Solé-Navais and Michelle M Murphy
Vitamin B12 after Birth and during Early Life
Rima Obeid, Pol SoléNavais and Michelle M Murphy
Cobalamin – Folate Interactions
Pol Solé-Navais, Rima Obeid and Michelle M Murphy
Extreme Vitamin B12 Concentrations in Clinical Practice in the Absence of Symptoms or B12 Treatment
Rima Obeid
Vitamin B12 and Drug Development
Jayme L. Workinger and Robert P. Doyle
