Description
Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders.The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.- Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics- Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics- Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications- Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases- Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Table of Contents
PrefaceJosé Luis García-Giménez1. Epigenetic Biomarkers: New findings, perspectives, and future directions in diagnosticsJosé Luis García-Giménez, Toshikazu Ushijima, and Trygve O. Tollefsbol2. The importance of Biobanks in epigenetic studiesLorena Peiró-Chova, Olga Bahamonde Ponce, Carolina Abril-Tormo, Jacobo Martínez-Santamaría, José Antonio López-Guerrero and Peter H.J. Riegman3. Epigenetic Mechanisms as Key Regulators in Disease. Clinical ImplicationsAbdelhalim Boukaba, José Luis García-Giménez4. The evolution of new technologies and methods in clinical epigenetics researchTandy L. Dolin Petrov and Nicole C. Riddle5. Biomarkers and methodologies for monitoring epigenetic drug effects in cancerMarianne B. Treppendahl, Lasse Sommer Kristensen and Kirsten Grønbæk6. Genome-wide techniques for the study of clinical epigenetic biomarkersEneda Toska and F Javier Carmona Sanz7. Sequenom MassARRAY technology for the analysis of DNA methylation. Clinical applicationsEnrique J. Buso and Marisa Iborra8. The role of Methylation-specific PCR and associated techniques in clinical diagnosticsFang Zhao and Bharati Bapat9. Pyrosequencing and its application in epigenetic clinical diagnosticsAna-Maria Florea10. Mass spectrometry for the identification of post-translational modifications in histones and its application in clinical epigeneticsRoberta Noberini, Alessandro Cuomo and Tiziana Bonaldi11. High-throughput analysis of non-coding RNAs: implications in clinical epigeneticsValerio Costa, Maria R Matarazzo, Miriam Gagliardi, Roberta Esposito, Alfredo Ciccodicola12. Circulating non-coding RNAs as clinical biomarkersFrancesco Russo, Flavia Scoyni, Alessandro Fatica, Marco Pellegrini, Alfredo Ferro, Alfredo Pulvirenti and Rosalba Giugno13. DNA methylation biomarkers in lung cancerJuan Sandoval and Paula Lopez Serra14. DNA methylation alterations as biomarkers for Prostate CancerJoão Ramalho-Carvalho, Rui Henrique, Carmen Jerónimo15. DNA methylation in breast cancerRaimundo Cervera, Alberto Ramos, Ana Lluch and Joan Climent16. DNA methylation in obesity and associated diseasesAna B Crujeiras and Angel Díaz-Lagares17. DNA Methylation Biomarkers in Asthma and AllergyAvery DeVries and Donata Vercelli18. DNA Methylation in Pregnancy ComplicationsDeepali Sundrani, Vinita Khot and Sadhana Joshi19. Epigenetics in Infectious DiseasesGenevieve Syn, Jenefer M. Blackwell and Sarra E. Jamieson20. DNA Methylation in Neurodegenerative DiseasesSahar Al-Mahdawi, Sara Anjomani Virmouni and Mark A. Pook21. The histone code and disease: post-translational modifications as potential prognostic factors for clinical diagnosisNicolas G. Simonet, George Rasti and Alejandro Vaquero22. Histone Post-Translational Modifications and Chromatin Remodelers in Prostate CancerFilipa Quintela Vieira, Diogo Almeida-Rios, Inês Graça, Rui Henrique and Carmen Jerónimo23. Histone post-translational modifications in breast cancer and their use in clinical diagnosis and prognosisLuca Magnani, Annita Louloupi and Wilbert Zwart24. Histone variants and post-translational modifications in spermatogenesis and infertilityJuan Ausio, Yinan Zhang and Toyotaka Ishibashi25. Circulating histones and nucleosomes as biomarkers in sepsis and septic shockJosé Luis García Giménez, Carlos Romá Mateo, Marta Seco Cervera, José Santiago Ibañez Cabellos and Federico V. Pallardó26. Chromatin landscape and epigenetic signatures in neurological disorders: emerging perspectives for biological and clinical researchPamela Milani and Ernest Fraenkel27. MicroRNAs deregulation in lung cancer and their use as clinical toolsPaula Lopez-Serra and Juan Sandoval28. Circulating Nucleic Acids as Prostate Cancer BiomarkersClaire E. Fletcher, Ailsa Sita-Lumsden, Akifumi Shibakawa and Charlotte L. Bevan29. microRNAs in breast cancer and their value as biomarkersOlafur Andri Stefansson30.
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- 電子書籍
- 絶対死なないステラ姫（４）
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- 洋書
- Book of Hare
