The role of the EGFR in intestinal stem cells : EGFR in small intestine and colon (2015. 108 S. 220 mm)

個数:

The role of the EGFR in intestinal stem cells : EGFR in small intestine and colon (2015. 108 S. 220 mm)

  • オンデマンド(OD/POD)版です。キャンセルは承れません。
  • 【入荷遅延について】
    世界情勢の影響により、海外からお取り寄せとなる洋書・洋古書の入荷が、表示している標準的な納期よりも遅延する場合がございます。
    おそれいりますが、あらかじめご了承くださいますようお願い申し上げます。
  • ◆画像の表紙や帯等は実物とは異なる場合があります。
  • ◆ウェブストアでの洋書販売価格は、弊社店舗等での販売価格とは異なります。
    また、洋書販売価格は、ご注文確定時点での日本円価格となります。
    ご注文確定後に、同じ洋書の販売価格が変動しても、それは反映されません。
  • 製本 Paperback:紙装版/ペーパーバック版/ページ数 108 p.
  • 商品コード 9783639856095

Description


(Text)
The small intestine can be divided in two parts: finger-like structures called villi cover the surface of the lumen and villi are surrounded by underlying pockets termed crypts. Both structures are covered with a columnar epithelium. The crypt base harbors LGR5+ stem cells and Paneth cells. Paneth cells are playing a very important role for stem cell function by secreting essential factors like Wnt, EGF and Notch ligands, and are also involved in the antimicrobial response. It has been shown that EGF is an essential survival factor for in vitro intestinal organoid cultures. However, its precise role for in vivo stem cell function has not yet been elucidated. I employed mice lacking the EGFR in different cell types of the intestine namely Lgr5+: (1) EGFRfl/fl LGR5CreERT2EGFP mice (2) EGFRfl/fl Villin Cre mice
(Author portrait)
Göcen, Vasfiye BilgeI was born and growup in Istanbul. At 15 I went to the Austrian High School and withMatura certificate I came to Austria and I graduated "Microbiologyand Genetics" as bachelor study and "Molecular Medicine" asMaster degree.

最近チェックした商品