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Full Description
One of the most interesting aspects of thermogenesis research is that it quite naturally attracts workers from an extremely wide spectrum of interests, ranging from the mechanism of cellular respiratory control at the molecular level and neuro-hormonal control of energy dissipation both at the cellular level and that of the whole organisms to the mechanism of temperature control during the hibernating cycle and that of cold acclimatation. Thus, the Satellite Symposium on "The Effectors of Thermogenesis" brought together not only physiologists, but also biochemists, pharmacologists, zoologists and clinicians, and provided a forum for the airing of new ideas as well as for the confrontation of different points of view. These are now reproduced in this book in exactly the same form and order in which they were presented at the Symposium, in the hope of providing a bird's-eye view of the various facets of thermogenesis research. A "mini-review", summarizing the current knowledge in each domain, therefore precedes the corresponding papers. The editors are deeply indebted to the contributors of these introductory lectures for so competently selecting from the mass of available information in each field, only the most essential elements. This book is dedicated to Dr. Robert Emrie Smith, a pioneer and path-finder in this field, who organized the first meeting on thermogenesis as a satellite of the XXI International Congress of Physiological Sciences and took an active part in the four subsequent meetings. L. Girardier DEDICATION Dr.
Contents
Control Mechanisms of Energy Dissipation in the Cytomembrane and Cytosol.- Plasma Membrane Involvement in Brown Fat Thermogenesis.- Does Cytoplasmic Alkalinization Trigger Mitochondrial Energy Dissipation in the Brown Adipocyte?.- Thresholds for Na+ and Ca++ Effects on Thermoregulation.- Catechol-O-Methyl Transferase Activity in Whole Brown Adipose Tissue of Rat in Vitro.- ?-Adrenergic Receptors in Brown Adipose Tissue: Identification by (-)[3H]Dihydroalprenolol Binding.- Control of Phosphoenolpyruvate Carboxykinase in Brown Adipose Tissue of Infant Rats.- The "Second Messenger" System in Brown Adipose Tissue of Developing Rats. Its Molecular Composition and Mechanism of Function.- Control Mechanisms of Energy Dissipation in the Mitochondria.- Energy Dissipation in Brown Adipose Tissue Mitochondria.- The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation.- Polyamine and Magnesium Effects on Mitochondrial Respiration in Control and Heat-Acclimated Rats.- Succinate Oxidation in Hamster Brown Adipocytes.- Energy Dissipation in Brown Fat.- 6-OH-Dopamine and the Development of Brown Adipose Tissue in the Cold.- Endocrine and Neural Control of Energy Dissipation.- Thermogenic Mechanisms and their Control.- Levels of Noradrenaline in Plasma During Thermogenesis Induced by Cold-Exposure or by Noradrenaline Infusion in Warm- and in Cold-Acclimated Rats.- Brown Adipose Tissue: The Dominant Site of Nonshivering Thermogenesis in the Rat.- Control of Brown Fat Thermogenesis by the Sympathetic Nervous System.- Hormonal Thermogenesis of "Non-Norepinephrine" Type.- "Cascade" Principle of the Control of Non-Shivering Thermogenesis by Intravenously Infused Noradrenaline.- Effects of Dietsand Cold Acclimation on Lipoprotein Lipase Activity and Cyclic Nucleotide Levels in Some Tissues of Rats.- Thyroid Thermogenesis.- Latency of Thyroid Hormone Action on Heat Production in the Rat.- Increased Cell Membrane Permeability to Na+ and K+ Induced by Thyroid Hormone in Rat Skeletal Muscle.- The Mechanism of the Respiratory and Transport Effect of Thyroid Hormone on Small Intestinal Mucosa.- Thyroidal Regulation of Renal Functions and of Renal Cortical Adenosine Triphosphatase Activity in the Rat.- Nutritionally-Induced Alterations in Thyroid Hormone Metabolism and Thermogenesis.- Non Shivering Thermogenesis and Implication of the Thyroid in Cold Labile and Cold Resistant Populations of the Golden Spiny Mouse (Acomys Russatus).- Energy Dissipation in the Organism: Hypometabolism, Cold Adaptation.- Role of Various Sites in Thermoregulatory Thermogenesis.- Glucocorticoids and Carbohydrate Metabolism in Hypothermic and Hibernating Hamsters.- Comparative Measurements of in Vitro Thermogenesis of Brown Adipose Tissue from Control and Cold Adapted Rats.- Hypothalamic Thermosensitivity in Mammals.- Studies onsome Thermogenetic Enzymes in Brown Adipose Tissue of Genetically Obese Mice.- Some Effects of Acute Cold Stress on Carbohydrate Metabolism in the Rat.- Free Fatty Acid and Glycerol Metabolism in Cold Exposed New-Born Rabbit.- The Role of the Body Mass: Body Surface Ratio in Thermoregulatory Responses to Cold, Hypoxia, and Hypercapnia in New-Born, Adult, and Aged Guinea Pigs.- Hibernation.- Hibernation as a Model for Studies on Thermogenesis and its Control.- Control of Non-Shivering Thermogenesis in a Hibernator.- Comparison of Induced and Spontaneous Arousals in Hibernating Hedgehogs.- Thermogenesis in Burn.- Metabolic and Hemodynamic Aspects of the Hypothermia of Early Burn Shock.- Metabolic & Thermoregulatory Responses to Thermal Injury.
