Cell Cycle Inhibitors in Cancer Therapy : Current Strategies (Cancer Drug Discovery and Development)

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Cell Cycle Inhibitors in Cancer Therapy : Current Strategies (Cancer Drug Discovery and Development)

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  • 製本 Hardcover:ハードカバー版/ページ数 400 p.
  • 言語 ENG
  • 商品コード 9780896039308
  • DDC分類 616.994061

Full Description

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Contents

Cdk Inhibitors: Background and Introduction
Giulia De Falco, Catherine Soprano, and Antonio Giordano

p27, A Prognostic Indicator Reflecting...?
Andrew Koff

Cell Cycle Control of Transcription at the G1/S Phase Transition
André J. van Wijnen, Gary S. Stein, Janet L. Stein, and Jane B. Lian

Tumor-Suppressor Genes as Diagnostic Tools
Lorenzo Leoncini, Cristiana Bellan, Caterina Cinti, and Antonio Giordano

Regulation of Cell Cycle and Apoptosis
Lucio Miele

CDK Inhibitors as Targets of Chemoprevention Agents
Joanna K. Sax and Wafik S. El-Deiry

Cell Cycle Regulatory Genes as Targets of Retinoids
Kenneth J. Soprano, Sijie Zhang, Dongmei Zhang, William F. Holmes, Valeria Masciullo, Antonio Giordano, and Dianne R. Soprano

Modulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the Treatment of Neoplastic Diseases
Adrian M. Senderowicz

Cell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis, and Treatment of Cancer
Paul J. van Diest and Rob J. A. M. Michalides

Cell Cycle Regulators as Targets of Anticancer Therapy
Mikhail V. Blagosklonny

Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer
Valeria Masciullo, Kenneth J. Soprano, and Antonio Giordano

Synthetic Oligopeptides as Cancer Cell Cycle Modulators
Anna Severino, Armando Felsani, Antonio Giordano, and Marco G. Paggi

Index