B型肝炎の発見<br>Hepatitis B : The Hunt for a Killer Virus

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B型肝炎の発見
Hepatitis B : The Hunt for a Killer Virus

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  • 製本 Paperback:紙装版/ペーパーバック版/ページ数 264 p.
  • 言語 ENG
  • 商品コード 9780691116235
  • DDC分類 610

基本説明

Describes how Blumberg and a team of researchers found a virus they were not looking for and created a vaccine for a disease they previously knew little about-work that took the author around the world and won him the Nobel Prize.

Full Description


About 375 million people are infected with the hepatitis B virus. It has killed more people than AIDS and also causes millions of cases of liver cancer. The discovery of this deadly virus and the vaccine against it--a vaccine that is sharply decreasing the infection rate worldwide and is probably the first effective cancer vaccine--was one of the great triumphs of twentieth-century medicine. And it almost didn't happen. With wit and insight, this scientific memoir and story of discovery describes how Baruch Blumberg and a team of researchers found a virus they were not looking for and created a vaccine for a disease they previously knew little about--work that took the author around the world and won him the Nobel Prize. Blumberg and his collaborators were investigating relationships between gene distribution and disease susceptibility, research that was yielding interesting data but no real breakthroughs. Many viewed their work as more field trip than science. But, through decades of hard work and investigative twists and turns, their pursuit led to the hepatitis B antigen, the elusive virus itself, and, ultimately, the vaccine.As he takes the reader through the detective work that culminated in his incredible discovery, the author recounts with immediacy exciting moments in the lab and in the field--from a hair-raising flight to Africa to an unpleasant encounter with Alaskan sled dogs. The hepatitis B story is more than a fascinating chronicle of a major discovery. What Blumberg followed to the virus was a trail of remarkable "accidents" that happen when scientists seek answers to interesting questions. Those events, combined with the investigator's determined persistence, resulted in studies that generated a pharmaceutical industry, have far-flung public-health applications, and saved millions of lives.

Table of Contents

Acknowledgments                                    xi
Introduction 1 (7)
Differences in Response to Disease 8 (21)
Oxford and the National Institutes of 29 (13)
Health: Inherited Variation and
Susceptibility to Disease
Polymorphisms and Geography: Disease, 42 (23)
Genetics, and Evolutionary Biology
We Discover a New Polymorphism: The Ag 65 (7)
System
The Discovery of Australia Antigen 72 (12)
What Is Australia Antigen? 84 (22)
Identifying the Hepatitis B Virus 106(13)
The Control of Posttransfusion Hepatitis 119(15)
The Hepatitis B Vaccine 134(13)
Hepatitis B Virus and Cancer of the Liver 147(12)
What Is Now Known about HBV? 159(34)
Back to Polymorphisms and Inherited 193(10)
Susceptibility to Disease
HBV and Its Connections: Current Research 203(12)
and the Future
Appendix 1 Scientists and Staff at Fox Chase 215(4)
Cancer Center Referred to in the Text
Appendix 2 Research on Hyaluronic Acid 219(2)
Appendix 3 The National Institutes of Health 221(2)
and the Funding of Basic Medical Research
Appendix 4 Molecular Biology 223(6)
Appendix 5 A Gazetteer of Selected Place-Names 229(4)
Used in the Text
Index 233