Biochemistry and Physiology of the Neutrophil


Biochemistry and Physiology of the Neutrophil

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  • 製本 Hardcover:ハードカバー版/ページ数 299 p.
  • 言語 ENG,ENG
  • 商品コード 9780521416986
  • DDC分類 612.112

Full Description

This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of these cells, highlighting the mechanisms by which they seek out and destroy pathogenic micro-organisms. The development of these cells during haematopoiesis is described and the mechanisms which lead to the production of reactive oxidants and the intracellular signal transduction systems which lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.

Table of Contents

1. Neutrophils and host defence: the fight
against infection
2. The development and structure of neutrophils
3. The generation and recognition of
neutrophil-activating factors: structure and
function of neutrophil receptors
4. The cytoskeleton: the molecular framework
regulating cell shape and the traffic of
intracellular components
5. The respiratory burst: the generation of
reactive oxygen metabolites and their role in
microbial killing
6. Neutrophil activation: the production of
intracellular signalling molecules
7. Neutrophil priming: regulation of neutrophil
function during inflammatory activation
8. Disorders of neutrophil function