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Perspectives in Supramolecular Chemistry will relate recent developments and new exciting approaches in supramolecular chemistry. In supramolecular chemistry, our aim is to understand the molecular chemistry beyond the covalent bond the series will concentrate on goal-orientated supramolecular chemistry. Perspectives in Supramolecular Chemistry will reflect research which develops supramolecular structures with specific new properties, such as recognition, transport and simulation of biosystems or new materials. The series will cover all areas from theoretical and modelling aspects through organic and inorganic chemistry and biochemistry to materials, solid-state and polymer sciences, reflecting the many and varied applications of supramolecular structures in modern chemistry. The Lock and Key Principle The State of the Art 100 Years on Edited by Jean-Paul Behr Published 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for further research.The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer's initial ideas. The Lock-and-Key Principle is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle, and will become the essential guide to the past, present and future of this remarkable idea. The interdisciplinary nature of this topic is highlighted in The Lock-and-Key Principle ensuring that this volume is essential reading for chemists, molecular biologists, biochemists and materials scientists working in the areas of molecular recognition, enzymology, immunology, protein and nucleic acid chemistry, crystallography, bioinorganic and bioorganic chemistry and supramolecular chemistry.
Table of Contents
Emil Fischer's Lock-and-Key Hypothesis After
100 Years--Towards a Supracellular Chemistry
Molecular Recognition in Biology: Models for
Analysis of Protein-Ligand Interactions (D.
Lancet, et al.).
New Biocatalysts via Chemical Modification
(I. Bell & D. Hilvert).
Oligonucleotides: Superspecific Ligands for
Targeting Nucleic Acids and Proteins and
Development of Molecular Devices (V. Vlassov).
Macrocycles and Antibodies as Catalysts (D.
Smithrud & S. Benkovic).
Lock-and-Key Processes at Crystalline
Interfaces: Relevance to the Spontaneous
Generation of Chirality (I. Weissbuch, et
A Model of the Origin of Life and
Perspectives in Supramolecular Engineering
(H. Kuhn & J. Waser).
Perspectives in Supramolecular
Chemistry--From the Lock-and-Key Image to the
Information Paradigm (J.-M.