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This text, examining the design of drugs to macromolecular targets, covers such topics as receptor fit technology; drug interactions with target enzymes of known structures; computer modelling of drug-DNA intercalative compounds; and perspectives in medicinal chemistry.
The role of macromolecules in drug action, G. Marshall; receptor fit technology, J.N. Champness and A.S. Gilbert; compounds designed to bind to haemoglobin, R. Wooton; drug interactions with target enzymes of known structures, B. Roth and D.K. Stammers; multiple modes of binding of thyroid hormones and other iodothyronines to human plasma transthyretin, P. de la Paz, et al; computer modelling of drug-DNA intercalative compounds, S. Neidle; protein crystallography, glycosomes and the design of new sleeping sickness drugs, W.G. Hol and R.K. Wierenga; perspectives in medicinal chemistry.