Addresses control of bone formation, resorption and remodelling, osteoblast differentiation and osteoclast activity, factors influencing dental extracellular matrix biomineralization, non-collagen proteins in bone and their function hormonal regulation of bone growth.
The cellular and molecular details of the formation, maintenance and repair of bones and teeth are now important areas of biomedical research. Techniques for isolating hard tissue macromolecules, including molecular cloning, have been perfected, and the ability to identify and manipulate cells associated with the formation and remodelling of hard tissues has been developed. In particular, it is possible to culture cells with retention of in vivo activity. This book brings together the latest research in the cellular and molecular biology of bones and teeth and considers its applications to medical and dental practice. The participants at the symposium were drawn from diverse fields, such as cell, molecular and developmental biology, endocrinology, inorganic chemistry and orthopaedic surgery. Subjects covered include: the control of bone formation, resorption and remodelling; osteoblast differentiation and osteoclast activity; factors influencing dental extracellular matrix biomineralization; non-collagen proteins in bone and their function; and hormonal regulation of bone growth, and bone-derived growth factors. The discussion after each paper serves to highlight future areas of research. The genetic basis of bone disease is considered, as is clinical bone repair.
Table of Contents
PARTIAL TABLE OF CONTENTS: Partial table of
Factors Influencing the Expression of Dental
Extracellular Matrix Biomineralization (H.
Slavkin, et al.).
Stromal Stem Cells: Marrow-Derived Osteogenic
Precursors (M. Owen & A. Friedenstein).
Osteoblastic Differentiation (P. Nijweide, et
Diversity of the Osteoblastic Phenotype (G.
Rodan, et al.).
The Regulation of Osteoclastic Development
and Function (T. Chambers).
Osteoblast Development: The Cell Surface and
the Bone Environment (P. Osdoby, et al.).
An Adhesion Variant of the MG-63 Osteosarcoma
Cell Line Displays and Osteoblast-Like
Phenotype (M. Pierschbacher, et al.).
Expression of Type I Procollagen Genes (D.
Prockop, et al.).
Phosphoproteins from Teeth and Bone (A. Veis).
Non-Collagen Proteins in Bone (J. Termine).