This book aims to provide a comprehensive and integrated survey of pathogenesis and immunity in the disease pertussis (whooping cough). It covers the molecular biology through vaccine manufacture and testing, to clinical medicine and epidemiology. The book contains 21 chapters by 31 authors from 6 countries, all acknowledged authorities and active researchers in the pertussis field. The main emphasis is on recent developments in knowledge of pertussis disease and the properties of pertussis vaccine.
Table of Contents
Growth of Bordetella Pertussis.
Genetics of Virulence of Bordetella Pertussis.
Bordetella Pertussis Adhesins.
Pertussis Toxin: Production, Purification,
Molecular Structure, and Assay.
The Multiple Biological Activities of
Metabolic Disturbances Produced by Pertussis
Action of Pertussigen (Pertussis Toxin) on
the Host Immune System.
Adenylate Cyclase Toxin of Bordetella
Heat-Labile Toxin of Bordetella Pertussis.
Tracheal Cytotoxin of Bordetella Pertussis.
Lipopolysaccharides of Bordetella Pertussis
Clinical Aspects of Pertussis.
Serological Responses to Pertussis.
Animal Models of Pertussis.
The Host-Parasite Relationship in Pertussis.
Efficacy of Whole-Cell Pertussis Vaccine.
Reactions to Whole-Cell Pertussis Vaccine.
Acellular and Defined-Component Vaccines
Evolution of Control Testing of Pertussis
Epidemiological Considerations for Whooping