Synthetic Peptides as Antigens (Ciba Foundation Symposia)

Synthetic Peptides as Antigens (Ciba Foundation Symposia)

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  • 製本 Paperback:紙装版/ペーパーバック版/ページ数 307 p.
  • 言語 ENG,ENG
  • 商品コード 9780471912033
  • DDC分類 616.0792

Full Description

Synthetic peptides as antigens Ciba Foundation Symposium 119 Chairman: Gordon L. Ada 1986 Vaccination is a major means of combating infectious disease but no effective vaccine is available yet for many parasitic, viral and bacterial infections. A new approach consists of vaccines based on synthetic peptides rather than native parent antigens. The contributors to this symposium discuss the antigenicity and immunogenicity of synthetic peptides and their potential use in vaccines against malaria and other serious diseases. They consider the relationship between protein conformation and antigenicity, including the role of localized mobility and the conformational changes induced when peptides bind with immunoglobulin. A new method of synthesizing peptides able to mimic discontinuous epitopes is described. The symposium opens with a review of the regulation of immune responses in vivo. Carrier molecules such as PPD are being investigated; carrier choice plays a crucial role in the anti-hCG vaccine (based on a synthetic peptide) being tested as a means of birth control, and discussed here. Synthetic peptides are also of use as research tools, as described for the analysis of IgG sites responsible for autoantibody production in rheumatoid arthritis, and the localization of the c-myc oncoprotein in normal and transformed cells and in tumour masses. Other Ciba Foundation Symposia published by Pitman: No 114: Fibrosis Chairman: A.J. Bailey 1985 ISBN 0 272 79814 2 No 116: Growth factors in biology and medicine Chairman: Sir Michael Stoker 1985 ISBN 0 272 79818 5 No 118: Biochemistry of macrophages Chairman: Z.A. Cohn 1986 ISBN 0 272 79822 3

Table of Contents

  Symposium on Synthetic Peptides as Antigens,
held at the Ciba Foundation, London, 4–6
June 1985
The subject of this symposium was proposed by
P. Dukor and D. G. Braun
Editors: Ruth Porter (Organizer) and Julie
G. L. Ada Introduction
J. H. Humphrey Regulation of in vivo immune
responses: few principles and much ignorance
P. J. Lachmann, L. Strangeways, A. Vyakarnam
and G. I. Evan Raising antibodies by coupling
peptides to PPD and immunizing BCG-sensitized
H. J. Dyson, K. J. Cross, J. Ostresh, R. A.
Houghten, I. A. Wilson, P. E. Wright and R.
A. Lerner Selection by site-directed
antibodies of small regions of peptides which
are ordered in water
M. H. V. Van Regenmortel, D. Altschuh and A.
Klug Influence of local structure on the
location of antigenic determinants in tobacco
mosaic virus protein
M. J. Crumpton The importance of conformation
and of equilibria in the interaction of
globular proteins and their fragments with
A. B. Edmundson and K. R. Ely
Three-dimensional analyses of the binding of
synthetic chemotactic and opioid peptides in
the Mcg light chain dimer
H. M. Geysen, S. J. Rodda and T. J. Mason The
delineation of peptides able to mimic
assembled epitopes
V. Nussenzweig and R. S. Nussenzweig
Experimental basis for the development of a
synthetic vaccine against Plasmodium
falciparum malaria sporozoites
R. F. Anders, P-T. Shi, D. B. Scanlon, S. J.
Leach, R. L. Coppel, G. V. Brown, H-D. Stahl
and D. J. Kemp Antigenic repeat structures in
proteins of Plasmodium falciparum
M. Sela, R. Arnon and C. O. Jacob Synthetic
peptides with antigenic specificity for
bacterial toxins
V. C. Stevens Use of synthetic peptides as
immunogens for developing a vaccine against
human chorionic gonadotropin
D. R. Stanworth, D. S. Butt and G. Z.
Hastings The use of synthetic peptides in the
delineation of immunoglobulin antigenic
epitopes and Fc effector functions
G. I. Evan, D.C. Hancock, T. Littlewood and
C. D. Pauza Characterization of the human
c-myc protein using antibodies prepared
against synthetic peptides
S. S. Alkan and D. G. Braun Epitope mapping
of human recombinant interferon alpha
molecules by monoclonal antibodies
Final general discussion Reactivity of
anti-peptide antibodies with the parent
The proportion of monoclonal antibodies
reactive to conformational or other linear
High and low affinity antibodies and their
T-dependent and T-independent antigen
G. L. Ada Chairman’s summing-up
Index of contributors
Subject index