Deals with the application of recombinant DNA techniques to the identification of diseases that have more than one inherited component.
Many common human diseases have a multifactorial origin: they are influenced by a person's genetic predisposition as well as by factors in the environment. This volume deals with the application of recombinant DNA techniques to the identification of diseases that have more than one inherited component. The polygenic factors responsible for coronary atherosclerosis provide a focus for this international symposium. Candidate genes are considered for apolipoproteins, low density lipoprotein receptors and various enzymes that influence coronary heart disease. Several other disorders having a polygenic origin are also discussed. These include hypertension, diabetes mellitus, psychiatric diseases and autoimmune (HLA-related) disorders. Problems raised by the study of different families or different populations are mentioned, as well as the possibility of applying molecular techniques to disease prevention - for example, through gene therapy. Some of the ethical issues that relate to human gene mapping are briefly explored.
Table of Contents
Introduction (D. Weatherall).
Human Gene Mapping (R. Williamson).
Genetics of Coronary Heart Disease and Its
Risk Factors (K. Berg).
The LDL Receptor: Oligonucleotide-Directed
Mutagenesis of the Cytoplasmic Domain (C.
Apolipoproteins, Quantitative Lipoprotein
Traits and Multifactorial Hyperlipidaemia (G.
Structure and Evolution of Human
Apolipoprotein Genes: Identification of
Regulatory Elements of the Human
Apolipoprotein E Gene (J. Taylor, et al).
General Discussion (DNA Polymorphisms,
Genetic Architecture of Inter-Individual
Variability in Apolipoprotein, Lipoprotein
and Lipid Phenotypes (C. Sing and E.