Parkinson's disease, Alzheimer's disease, and motor neuron disease (amyotrophic lateral sclerosis) share a significant common feature: selective death of neurons in restricted regions of the brain. In this international symposium - the first to bring together neurophysiologists working on neuronal death and neuropathologists dealing with human degenerative brain disease - the participants describe the causes and sequence of events leading to neuronal death and discuss what can be done to prevent it. Among the topics covered in the symposium are recent advances in the understanding of agents that are known to be involved in neuronal death, examples of neuronal death during normal development, and the role played by endocrine mechanisms and neuronal activity. These topics are discussed in relation to possible causes of specific human diseases. Trophic factors controlling the survival of neuronal transplants are considered, as are the therapeutic prospects for tissue transplantation. This interdisciplinary symposium summarizes the most recent information on these degenerative brain diseases and suggests new directions for research. Neurobiologists, neuropathologists, clinical neurologists, psychiatrists and cell biologists will all find this book stimulating. It should also interest clinicians, particularly those working in geriatric medicine.
Table of Contents
PARTIAL TABLE OF CONTENTS: Partial table of
Nerve Cell Death in Degenerative Diseases of
the Central Nervous System: Clinical Aspects
(Y. Agid & J. Blin).
Dysfunction and Death of Neurons in Human
Degenerative Neurological Diseases and in
Animal Models (D. L. Price, et al.).
Neuronal Origin of Cerebral Amyloidogenic
Proteins: Their Role in Alzheimer's Disease
and Unconventional Virus Diseases of the
Nervous System (C. L. Masters & K.
Mechanism for Programmed Cell Death in the
Nervous System of a Moth (S.E.
Fahrbach & J. W.
Neurotrophic Factors and Neuronal Death (H.
Thoenen, et al.).
Muscle Activity and Motor Neuron Death in the
Spinal Cord of the Chick Embryo (R. W.
Remodelling of Early Axonal Projections
Through the Selective Elimination of Neurons
and Long Axon Collaterals (D. D. M.