Topics include the interactions between antidepressants and various receptor sites inside and outside the brain, animal models for the study of depression, and possible similarities between the action of antidepressants and electroconvulsive theraphy.
Ciba Foundation Symposium 123 Antidepressants and Receptor Function Chairman: Dennis Murphy 1986 Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha-and beta-adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys. This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists. Related Ciba Foundation Symposia: No 117 Photoperiodism, melatonin and the pineal Chairman: R. V. Short 1985 ISBN 0 471 91086 4 No 126 Selective Neuronal Death Chairman: H. M. Wisniewski 1987 ISBN 0 471 91092 9
Table of Contents
Symposium on Depression, antidepressants and
receptor sensitivity, held at the Ciba
Foundation, London, 1921 November 1985
Editors: Ruth Porter, Gregory Bock
(Organizer) and Sarah Clark
D. Murphy Introduction
S.Z. Langer, A.M. Galzin, C.R. Lee and H.
Schoemaker Antidepressant-binding sites in
brain and platelets
W.H. Berrettini, J. Bardakjian, A.L. Barnett
Jr, J.I. Nurnberger Jr and E.S. Gershon
-Adrenoceptor function in human adult skin
fibroblasts: a study of manic-depressive
P. Propping, W. Friedl, J. Hebebrand and K-U.
Lentes Genetic studies at the receptor level:
investigations in human twins and
M. Åsberg and A. Wägner Biochemical
effects of antidepressant
treatmentstudies of monoamine
metabolites in cerebrospinal fluid and
platelet [3Himipramine binding
R.W. Horton, C.L.E. Katona, A.E. Theodorou,
A.S. Hale, S.L. Davies, C. Tunnicliffe, Y.
Yamaguchi, E.S. Paykel and J.S. Kelly
Platelet radioligand binding and
neuroendocrine challenge tests in depression
D.L. Murphy, C.S. Aulakh and N. A. Garrick
How antidepressants work: cautionary
conclusions based on clinical and laboratory
studies of the longer-term consequences of
monoamine oxidase-inhibiting antidepressants
S.A. Checkley, T.H. Corn, I.B. Glass, C.
Thompson, C. Franey and J. Arendt
Neuroendocrine and other studies of the
mechanism of antidepressant action of
L.J. Siever, E.F. Coccaro, E. Benjamin, K.
Rubinstein and K.L. Davis Adrenergic and
serotonergic receptor responsiveness in
General discussion I
A. Frazer, G. Ordway, J. ODonnell, P.
Vos and B. Wolfe Effect of repeated
administration of clenbuterol on the
regulation of -adrenoceptors in the central
nervous system of the rat
J.M. Weiss and P.G. Simson Depression in an
animal model: focus on the locus ceruleus
G.W. Kraemer Causes of changes in brain
noradrenaline systems and later effects on
responses to social stressors in rhesus
monkeys: the cascade hypothesis
J. Vetulani, L. Antkiewicz-Michaluk, A.
Rokosz-Pelc and J. Michaluk Effects of
chronically administered antidepressants and
electroconvulsive treatment on cerebral
neurotransmitter receptors in rodents with
A.R. Green, D.J. Heal and G.M. Goodwin The
effects of electroconvulsive therapy and
antidepressant drugs on monoamine receptors
in rodent brainsimilarities and
General discussion II
Index of contributors