Photoperiodism, Melatonin and the Pineal (Ciba Foundation Symposia)

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Photoperiodism, Melatonin and the Pineal (Ciba Foundation Symposia)

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  • 製本 Hardcover:ハードカバー版/ページ数 320 p.
  • 言語 ENG,ENG
  • 商品コード 9780471910862
  • DDC分類 573

Full Description

Photoperiodism, melatonin and the pineal Ciba Foundation Symposium 117 Chairman: R.V. Short 1985 Melatonin was isolated from the mammalian pineal in 1985, but only relatively recently, as the Chairman points out, has evidence accumulated for its role as the Hormone of Darkness, the Hourglass of Time'. The rhythmic melatonin signal from the pineal appears to provide information about photoperiod in many species that show seasonal cycles in reproduction, moulting and other processes. But how do animals respond to the pineal melatonin signal? What determines photoperiodism in birds, which do not seem to use this signal to regulate breeding? What is the significance of retinal melatonin? Does melatonin have a function in humans? These are amongst the issues considered at the symposium recorded in this book. In addition to the morphology and photoneural control of the pineal, the contributors describe the effects of melatonin and of manipulating photoperiod in several laboratory and economically important species - hormones, seasonal cycles, circadian rhythms and influences during development and sexual maturation have been studied. In humans, the possible significance of melatonin in puberty, malignant disease and affective disorders is considered, as are results suggesting that melatonin can entrain fatigue (or alertness), with discussion of the therapeutic potential of this hormone in certain disturbances of biological rhythm, including jet lag. This book should be of interest to physiologists, neuropharmacologists, endocrinologists, behavioural biologists, psychologists and clinical investigators with a special interest in the pineal. Other Ciba Foundation Symposia published by Pitman: No 102: Origins and development of adaptation Chairman: B.C. Clarke 1984 ISBN 0 272 79749 9 No 104: Photoperiodic regulation of insect and molluscan hormones Chairman: W. Mordue 1984 ISBN 0 272 79751 0 No 113: Retinoids, differentiation and disease Chairman: M.B. Sporn 1985 ISBN 0 272 79813 4

Table of Contents

  Symposium on Melatonin and the pineal, held
at the Ciba Foundation, London, 5–7
March 1985
The subject of this symposium was proposed by
Professor V. Marks and Dr J. Arendt
Editors: David Evered (Organizer) and Sarah
R. V. Short Photoperiodism, melatonin and the
pineal: it’s only a question of time
L. Vollrath Mammalian pinealocytes:
ultrastructural aspects and innervation
M. C. Moore-Ede and M. L. Moline Circadian
rhythms and photoperiodism
D. C. Klein Photoneural regulation of the
mammalian pineal gland
M. H. Hastings, J. Herbert, N. D. Martensz
and A. C. Roberts Melatonin and the brain in
photoperiodic mammals
M. Menaker Eyes—the second (and third)
pineal glands?
B. K. Follett, R. G. Foster and T. J.
Nicholls Photoperiodism in birds
General discussion I Local and cellular
actions of melatonin 106 Retinal rhythms 107
Light sensitivity and melatonin synthesis
S. M. Reppert, M. J. Duncan and B. D. Goldman
Photic influences on the developing mammal
G. A. Lincoln, F. J. P. Ebling and O. F. X.
Almelda Generation of melatonin rhythms
E. L. Bittman The role of rhythms in the
response to melatonin
L. Martinet and D. Allain Role of the pineal
gland in the photoperiodic control of
reproductive and non-reproductive functions
in mink (Mustela vison)
S. M. Armstrong and J. Redman Melatonin
administration: effects on rodent circadian
P. C. Sizonenko, U. Lang, R. W. Rivest and M.
L. Aubert The pineal and pubertal development
A. J. Lewy, R. L. Sack and C. M. Singer
Melatonin, light and chronobiological
L. Wetterberg Melatonin and affective
J. Arendt, C. Bojkowski, S. Folkard, C.
Franey, V. Marks, D. Minors, J. Waterhouse,
R. A. Wever, C. Wildgruber and J. Wright Some
effects of melatonin and the control of its
secretion in humans
L. Tamarkin, O. F. X. Almeida and D. N.
Danforth Jr Melatonin and malignant disease
General discussion II Melatonin assay
technology 300 How important is the duration
of the melatonin signal?
Index of contributors
Subject index