This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience.
Table of Contents
Introduction: The Rationale of Clinical
The Historical Development of Clinical Trials.
Organization and Planning.
The Justificaton for Randomized Controlled
Methods of Randomization.
Blinding and Placebos.
The Size of a Clinical Trial.
Monitoring Trial Progress.
Forms and Data Management.
Basic Principles of Statistical Analysis.
Further Aspects of Data Analysis.
Publication and Interpretation of Findings.