There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal--containing species. In keeping with the notion that healthy mammals rely on (bio--essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal--based and considerable effort is being devoted to developing both second-- and third--generation drugs as well as generating novel metal--based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal--based drugs.The following are also covered: non--invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal--based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.
List of Contributors. Preface. 1. 3Li Lithium Metallotherapeutics (Robin S.B. Williams and Adrian J. Harwood). 2. 5B Boron Compounds as Therapeutic Drugs (Geeta Rana, Kamesh Vyakaranam, John A. Maguire and Narayan S. Hosmane). 3. 12Mg The Role of Magnesium as a Metallotherapeutic Drug (Pietro Delva). 4. 13Al Aluminum Metallotherapeutics (Thanos Salifoglou). 5. 14Si Biological Activity of Organosilicon Compounds (Edmunds Lukevics and Luba Ignatovich). 6. 20Ca The Role of Calcium as a Metallotherapeutic Drug (Mario Barbagallo and Ligia J. Dominguez). 7. 22Ti Anti-tumor Titanium Drugs (Erich Dubler). 8. 23V Insulin-Mimetic Vanadium-Containing Compounds (Tamts Kiss and Tamts Jakusch). 9. 25Mn Manganese Metallotherapeutics (Jeanne H. Freeland-Graves, Tanushree Bose and Abbass Karbassian). 10. 26Fe The Use of Iron-Based Drugs in Medicine (Xiang Wu and Mei Lin Go). 11. 27Co Cobalt Complexes as Potential Pharmaceutical Agents (Hui Chao and Liang-Nian Ji). 12. 29Cu Chemotherapeutic Copper Compounds (Francisco Gonzalez-Vilchez and Rosario Vilaplana). 13. 30Zn The Role of Zinc as a Metallotherapeutic Agent (Jane V. Higdon and Emily Ho). 14. 31Ga Therapeutic Gallium Compounds (Lawrence R. Bernstein). 15. 32Ge Biological Activity of Organogermanium Compounds (Edmunds Lukevics and Luba Ignatovich). 16. 33As Metallotherapeutic Arsenic Compounds (Paul C. Ho). 17. 34Se The Use of Selenium-Based Drugs in Medicine (Michael Carland and Tahli Fenner). 18. 43Tc Technetium in Medicine (Oyebola O. Sogbein and John F. Valliant). 19. 44Ru Perspectives of Ruthenium Complexes in Cancer Therapy (Olivier Lentzen, Cecile Moucheron and Andree Kirsch-De Mesmaeker). 20. 45Rh Rhodium in Medicine (Florian P. Pruchnik). 21. 46Pd The Use of Palladium Complexes in Medicine (Achilleas Garoufis, Sotiris K. Hadjikakou and Nick Hadjiliadis). 22. 50Sn Tin Compounds and Their Therapeutic Potential (Marcel Gielen and Edward R.T. Tiekink). 23. 51Sb Antimony in Medicine (Siucheong Yan, Lan Jin and Hongzhe Sun). 24. 75Re Therapeutic Rhenium Radiopharmaceuticals (Jonathan R. Dilworth and Paul S. Donnelly). 25. 78Pt Platinum-Based Drugs (Viktor Brabec and Jana Kasparkova). 26. 79Au Gold-Based Metallotherapeutics: Use and Potential (Soo Yei Ho and Edward R.T. Tiekink). 27. 83Bi Bismuth-Based Pharmaceuticals (Neil Burford and Melanie D. Eelman). 28. Paramagnetic Metal Complexes as Contrast Agents for Magnetic Resonance Imaging (Silvio Aime, Alessandro Barge, Eliana Gianolio, Simonetta Geninatti Crich, Walter Dastru and Fulvio Uggeri). Index.