Essentials of Chemical Biology : Structure and Dynamics of Biological Macromolecules

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Essentials of Chemical Biology : Structure and Dynamics of Biological Macromolecules

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  • 製本 Paperback:紙装版/ペーパーバック版/ページ数 573 p.
  • 言語 ENG
  • 商品コード 9780470845318
  • DDC分類 572

Full Description

"This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules...This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended..." CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research. This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses.This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry. Key Features: A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.

Table of Contents

Preface                                            ix
Glossary of physical terms xi
The structures of biological macromolecules 1 (92)
and lipid assemblies
General introduction 1 (3)
Protein structure 4 (22)
Carbohydrate structure 26 (15)
Nucleic acid structure 41 (28)
Macromolecular lipid assemblies 69 (12)
Structural forces in biological 81 (12)
Chemical and biological synthesis 93 (46)
Introduction to synthesis in chemical 93 (1)
Chemical synthesis of peptides and 94 (8)
Chemical synthesis of nucleic acids 102(9)
Chemical synthesis of oligosaccharides 111(7)
Chemical synthesis of lipids 118(1)
Biological synthesis of biological 119(10)
Directed biological synthesis of proteins 129(8)
Biological syntheses of nucleic acids, 137(2)
oligosaccharides and lipids
Molecular biology as a toolset for chemical 139(36)
Key concepts in molecular biology 139(5)
Tools and techniques in molecular biology 144(13)
Cloning and identification of genes in DNA 157(9)
Integrating cloning and expression 166(4)
Site-directed mutagenesis 170(5)
Electronic and vibrational spectroscopy 175(50)
Electronic and vibrational spectroscopy 175(1)
in chemical biology
UV-visible spectroscopy 176(7)
Circular dichroism spectroscopy 183(6)
Vibrational spectroscopy 189(4)
Fluorescence spectroscopy 193(29)
Probing metal centres by absorption 222(3)
Magnetic resonance 225(48)
Magnetic resonance in chemical biology 225(1)
Key principles of NMR 226(16)
Two-dimensional NMR 242(5)
Multi-dimensional NMR 247(5)
Biological macromolecule structural 252(14)
EPR spectroscopy; key principles 266(7)
Diffraction and microscopy 273(48)
Diffraction and microscopy in chemical 273(1)
Key principles of X-ray diffraction 274(9)
Structural information from X-ray 283(14)
Neutron diffraction 297(2)
Key principles of electron microscopy 299(10)
Key principles of scanning probe 309(12)
Molecular recognition and binding 321(64)
Molecular recognition and binding in 321(19)
chemical biology
Theoretical models of binding 340(8)
Analysing molecular recognition and 348(17)
Biological molecular recognition studies 365(20)
Kinetic and catalysis 385(90)
Catalysis in chemical biology 385(23)
Steady state kinetic schemes 408(33)
Pre-steady-state kinetics 441(7)
Theories of biocatalysis 448(23)
Electron transfer 471(4)
Mass spectrometry and proteomics 475(38)
Mass spectrometry in chemical biology 475(2)
Key principles in mass spectrometry 477(13)
Structural analysis of biological 490(9)
macromolecules and lipids by mass
The challenge of proteomics 499(10)
Genomics - assigning function to genes 509(4)
and proteins
Molecular selection and evolution 513(30)
Chemical biology and the origins of life 513(5)
Molecular breeding; natural selection 518(4)
acting on self-organisation
Directed evolution of protein function 522(8)
Directed evolution of nucleic acids 530(9)
Catalytic antibodies 539(4)
References 543(12)
Index 555