The Pulmonary Endothelium : Function in Health and Disease

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The Pulmonary Endothelium : Function in Health and Disease

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  • 製本 Hardcover:ハードカバー版/ページ数 512 p.
  • 言語 ENG
  • 商品コード 9780470723616
  • DDC分類 612.2

Full Description


The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals - specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.

Contents

List of Contributors xi Introduction Sharon Rounds and Norbert Voelkel xvii SECTION I: NORMAL PULMONARY ENDOTHELIUM. STRUCTURE, FUNCTION, CELL BIOLOGY 1 1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis Margaret A. Schwarz and Ondine B. Cleaver 3 2: Anatomy of the Pulmonary Endothelium Radu V. Stan 25 3: Cadherins and Connexins in Pulmonary Endothelial Function Kaushik Parthasarathi and Sadiqa K. Quadri 33 4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix Katie L. Grinnell and Elizabeth O. Harrington 51 5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta 73 6: Pulmonary Endothelium and Nitric Oxide Yunchao Su and Edward R. Block 89 7: Pulmonary Endothelial Cell Surface Metabolic Functions Usamah S. Kayyali and Barry L. Fanburg 105 8: Cell Biology of Lung Endothelial Permeability Guochang Hu and Richard D. Minshall 113 9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels Donna L. Cioffi, Songwei Wu and Troy Stevens 129 10: Pulmonary Endothelial Interactions with Leukocytes and Platelets Rosana Souza Rodrigues and Guy A. Zimmerman 143 11: Mesenchymal--Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation Kurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid 167 12: Pulmonary Endothelium and Vasomotor Control Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta 185 13: Pulmonary Endothelial Progenitor Cells Bernard Thebaud and Mervin C. Yoder 203 14: Bronchial Vasculature: The Other Pulmonary Circulation Elizabeth Wagner 217 15: Mapping Protein Expression on Pulmonary Vascular Endothelium Kerri A. Massey and Jan E. Schnitzer 229 SECTION II: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis Qing Lu and Sharon Rounds 243 17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium Kenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher 261 18: Hypoxia and the Pulmonary Endothelium Matthew Jankowich, Gaurav Choudhary and Sharon Rounds 287 19: Viral Infection and Pulmonary Endothelial Cells Norbert F. Voelkel 303 20: Effects of Pressure and Flow on the Pulmonary Endothelium Wolfgang M. Kuebler 309 21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia 337 22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium Vladimir R. Muzykantov 355 Regulation of the Pulmonary Circulation in the Fetus and Newborn Yuansheng Gao and J. Usha Raj 381 24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia 399 25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel 417 26: Role of the Endothelium in Emphysema: Emphysema -- A Lung Microvascular Disease Norbert F. Voelkel and Ramesh Natarajan 437 27: Pulmonary Endothelium and Pulmonary Hypertension Rubin M. Tuder and Serpil C. Erzurum 449 28: Collagen Vascular Diseases and Pulmonary Endothelium Pradeep R. Rai and Carlyne D. Cool 461 29: Pulmonary Endothelium in Thromboembolism Irene M. Lang 471 30: Pulmonary Endothelium and Malignancies Abu-Bakr Al-Mehdi 485 Epilogue Norbert F. Voelkel 491 Index 495