Do Seizures Damage the Brain (Progress in Brain Research)

Do Seizures Damage the Brain (Progress in Brain Research)

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  • 製本 Hardcover:ハードカバー版/ページ数 520 p.
  • 言語 ENG,ENG
  • 商品コード 9780444508140
  • DDC分類 616.845

Full Description

What are the consequences, if any, of repeated brief seizures that are the defining feature of epilepsy? A firm answer to this question has been surprisingly elusive for a variety of reasons. Clearly there is a subset of patients who appear to tolerate seizures with relatively limited long-term consequences, and not all patients are destined to progress to intractability with frequent seizures and disability. This variability and individual susceptibility has made it difficult to make statements that fairly apply to the full range of people with epileptic disorders, whose disorders span a broad spectrum from mild with excellent control and few limitations, to severe with multiple daily seizures and pronounced disability that affects employment, educational performance and personal life. This volume seeks to explore the spectrum of severe to more subtle damage that may be a consequence of seizures. The contributing authors have addressed these questions and related issues using a variety of methods in experimental models and in patients with epilepsy.

Table of Contents

        List of Contributors                       v
Preface xi
Acknowledgements xiii
Section I. Seizure-induced damage in
experimental epilepsy
Concept of activity-induced cell death in 3 (10)
epilepsy: historical and contemporary
B.S. Meldrum
Are seizures harmful: what can we learn from 13 (12)
animal models?
A.J. Cole
S. Koh
Y. Zheng
Doubt and certainty in counting 25 (18)
R.W. Guillery
B.K. August
Design-based stereological methods for 43 (10)
counting neurons
M.J. West
The course of cellular alterations associated 53 (14)
with the development of spontaneous seizures
after status epilepticus
F.E. Dudek
J.L. Hellier
P.A. Williams
D.J. Ferraro
K.J. Staley
Progression of neuronal damage after status 67 (18)
epilepticus and during spontaneous seizures
in a rat model of temporal lobe epilepsy
A. Pitkanen
J. Nissinen
J. Nairismagi
K. Lukasiuk
O.H.J. Grohn
R. Miettinen
R. Kauppinen
Does convulsive status epilepticus (SE) 85 (10)
result in cerebral damage or affect the
course of epilepsy --- the epidemiological
and clinical evidence?
S. Shorvon
Repeated brief seizures induce progressive 95 (16)
hippocampal neuron loss and memory deficits
R. Kotloski
M. Lynch
S. Lauersdorf
T. Sutula
Neuronal apoptosis after brief and prolonged 111 (10)
J. Bengzon
P. Mohapel
C. Ekdahl
O. Lindvall
Seizure-induced neurogenesis: are more new 121 (12)
neurons good for an adult brain?
J.M. Parent
D.H. Lowenstein
Summary: Seizure-induced damage in 133 (6)
experimental models
T. Sutula
A. Pitkanen
Section II. Mechanisms of seizure-induced damage
Complications associated with genetic 139 (10)
background effects in models of experimental
P.E. Schauwecker
Genomics and neurological phenotypes: 149 (12)
applications for seizure-induced damage
J.A. Del Rio
C. Barlow
Functional genomics in experimental and human 161 (14)
temporal lobe epilepsy: powerful new tools to
identify molecular disease mechanisms of
hippocampal damage
A.J. Becker
O.D. Wiestler
I. Blumcke
What synaptic lipid signaling tells us about 175 (12)
seizure-induced damage and epileptogenesis
N.G. Bazan
B. Tu
E.B. Rodriguez de Turco
The role of mitochondria and oxidative stress 187 (10)
in neuronal damage after brief and prolonged
H.R. Cock
Cell death and metabolic activity during 197 (14)
epileptiform discharges and status
epilepticus in the hippocampus
U. Heinemann
K. Buchheim
S. Gabriel
O. Kann
R. Kovacs
S. Schuchmann
Summary: Mechanisms of seizure-induced damage 211 (4)
T. Sutula
A. Pitkanen
Section III. Evidence for seizure-induced
damage in human studies: epidemiology,
pathology, imaging and clinical studies
Do seizures beget seizures? 215 (6)
W.A. Hauser
J.R. Lee
Do occasional brief seizures cause detectable 221 (16)
clinical consequences?
S. Shinnar
W.A. Hauser
Hippocampal neuron damage in human epilepsy: 237 (16)
Meyer's hypothesis revisited
G.W. Mathern
P.D. Adelson
L.D. Cahan
J.P. Leite
MRI studies. Do seizures damage the brain? 253 (10)
J.S. Duncan
Do prolonged febrile seizures produce medial 263 (16)
temporal sclerosis? Hypotheses, MRI evidence
and unanswered questions
D.V. Lewis
D. Barboriak
J.R. MacFall
J.M. Provenzale
T.V. Mitchell
K.E. VanLandingham
Do recurrent seizures cause neuronal damage? 279 (18)
A series of studies with MRI volumetry in
adults with partial epilepsy
R. Kalviainen
T. Salmenpera
Proton magnetic resonance spectroscopic 297 (8)
imaging suggests progressive neuronal damage
in human temporal lobe epilepsy
A. Bernasconi
E. Tasch
F. Cendes
L.M. Li
D.L. Arnold
Neuroimaging and the progression of epilepsy 305 (10)
W.H. Theodore
W.D. Gaillard
Summary: Evidence for seizure-induced damage 315 (6)
in human studies: epidemiology, pathology,
imaging, and clinical studies
T. Sutula
A. Pitkanen
Section IV. Seizure-induced cell death in
development and functional consequences
Seizure-induced damage in the developing 321 (14)
human: relevance of experimental models
G.L. Holmes
R. Khazipov
Y. Ben-Ari
Seizure-induced neuronal death in the 335 (20)
immature brain
C.G. Wasterlain
J. Niquet
K.W. Thompson
H. Liu
R. Sankar
A.M. Mazarati
D. Naylor
H. Katsumori
L. Suchomelova
Y. Shirasaka
Effects of brief seizures during development 355 (10)
L. Velisek
S.L. Moshe
Is neuronal death required for 365 (12)
seizure-induced epileptogenesis in the
immature brain?
T.Z. Baram
M. Eghbal-Ahmadi
R.A. Bender
Assessing the behavioral and cognitive 377 (14)
effects of seizures on the developing brain
C.E. Stafstrom
Recent experimental studies of the effects of 391 (4)
seizures on brain development
J.W. Swann
Summary: Seizure-induced damage in 395 (4)
development and functional consequences
T. Sutula
A. Pitkanen
Section V. Neuropsychological consequences of
human epilepsy
Progressive cognitive decline in adolescents 399 (10)
and adults with epilepsy
C.B. Dodrill
Progressive cognitive decline in epilepsy: an 409 (10)
indication of ongoing plasticity
H. Stefan
E. Pauli
Progressive behavioral changes in children 419 (10)
with epilepsy
J.K. Austin
D.W. Dunn
The neurodevelopmental impact of childhood 429 (10)
onset temporal lobe epilepsy on brain
structure and function and the risk of
progressive cognitive effects
B.P. Hermann
M. Seidenberg
B. Bell
Effects of chronic epilepsy on declarative 439 (16)
memory systems
C. Helmstaedter
Effects of chronic epilepsy on intellectual 455 (10)
H. Jokeit
A. Ebner
Summary: neuropsychological consequences of 465 (6)
human epilepsy
T. Sutula
A. Pitkanen
Section VI. Implications for management
Will brain damage after status epilepticus be 471 (8)
history in 2010?
D.M. Treiman
Is complete seizure control imperative? 479 (8)
F. Andermann
Implications for neuroprotective treatments 487 (10)
B.S. Meldrum
Development of neuroprotective compounds in 497 (12)
the pharmaceutical industry: Where are we,
and where are we going?
N. Santilli
So what can we conclude --- do seizures 509 (4)
damage the brain?
J. Engel Jr.
Summary: Implications for management 513 (2)
T. Sutula
A. Pitkanen
Subject Index 515